Acetyl-L-carnitine (ALCAR) is a mitochondrial carrier compound that crosses the blood-brain barrier. Strongest evidence is for diabetic neuropathy, age-related cognitive decline, and mental fatigue.
ALCAR significantly improved nerve fiber regeneration, vibration perception, and pain scores in diabetic neuropathy vs placebo.
ALCAR significantly reduced physical and mental fatigue scores in older adults, post-illness recovery, and chronic fatigue syndromes.
ALCAR produced significant improvements in cognitive function scales in mild cognitive impairment and early Alzheimer's vs placebo.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.