Ingredients · B-Complex · Research
Clinical research

What does the research say about B-Complex?

strong evidence

B-vitamins are essential cofactors for energy, neurotransmitter synthesis, and methylation. Activated forms (methylfolate, methylcobalamin, P-5-P) bypass common genetic absorption issues.

Best-evidenced use cases
  • Stress with elevated cortisol
  • Energy support
  • MTHFR variants (methylated forms)
  • Vegetarian/vegan supplementation
  • Stress-induced cognitive fatigue

2 key studies

Search PubMed for more
  • 01RCT2010Human Psychopharmacology

    B-vitamin complex and stress

    Kennedy et al.
    Sample
    60 healthy adults
    Dose
    High-dose B-complex
    Duration
    33 days
    Key finding

    B-complex significantly reduced stress, fatigue, and mental fatigue in healthy adults exposed to chronic occupational stress.

    Read on PubMed
  • 02Meta-analysis2002BMJ

    B-vitamins and homocysteine reduction

    Clarke et al.
    Sample
    12 RCTs
    Dose
    Various
    Duration
    Variable
    Key finding

    B6, B12, and folate supplementation produced consistent reductions in homocysteine, a cardiovascular risk marker.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

Make it actionable

See B-Complex in a personalised stack

The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.