Home/Ingredients/Calcium AKG (Alpha-Ketoglutarate)
SPECIALTY

Calcium AKG (Alpha-Ketoglutarate)

Cellular energy · longevity · epigenetic clock

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Calcium AKG: Cellular energy · longevity · epigenetic clock. A Krebs cycle metabolite that supports mitochondrial energy and has shown promising effects on biological age markers. Standard dose 1000 mg, taken in the morning, about $35/month. Evidence rating: moderate evidence.

What is Calcium AKG?

Calcium alpha-ketoglutarate (Ca-AKG) is a metabolic intermediate in the Krebs cycle and a key player in cellular energy production, collagen synthesis, and epigenetic regulation. AKG levels decline approximately 10-fold by age 80. In animal studies, AKG supplementation extended median lifespan by 12% and compressed end-of-life frailty. A 2021 human pilot study from the Buck Institute reported an average 8-year reduction in biological age (measured by DNA methylation clocks) after 7 months of supplementation. Standard dose is 1,000 mg per day, taken with food.

WHY IT MATTERS

A Krebs cycle metabolite that supports mitochondrial energy and has shown promising effects on biological age markers.

Where to buy

Life Extension GEROPROTECT Ageless Cell
RECOMMENDED
Life Extension, Calcium AKG
1000 mg · Morning · ~$35/month

suppdoc.io is an affiliate. Links may earn us a commission at no extra cost to you.

Best for your goal

Interactions

Other specialty

Elderberry Extract
Immune support · seasonal
Berberine HCl
Blood sugar · metabolic health · gut
Milk Thistle (Silymarin)
Liver support · antioxidant
ZMA (Zn + Mg + B6)
Sleep · recovery · testosterone (male)

Common questions

What is Calcium AKG?
Calcium alpha-ketoglutarate (Ca-AKG) is a metabolic intermediate in the Krebs cycle and a key player in cellular energy production, collagen synthesis, and epigenetic regulation. AKG levels decline approximately 10-fold by age 80. In animal studies, AKG supplementation extended median lifespan by 12% and compressed end-of-life frailty. A 2021 human pilot study from the Buck Institute reported an average 8-year reduction in biological age (measured by DNA methylation clocks) after 7 months of supplementation. Standard dose is 1,000 mg per day, taken with food.
What is Calcium AKG used for?
Cellular energy · longevity · epigenetic clock. A Krebs cycle metabolite that supports mitochondrial energy and has shown promising effects on biological age markers.
What is the standard dose of Calcium AKG?
1000 mg, typically taken in the morning. Approximate cost is $35 per month.
How strong is the evidence for Calcium AKG?
Moderate evidence for its primary uses. See the full study list on the research page.

Not sure if Calcium AKG is right for you?

Take our quiz. We'll compose a personalised stack that fits your goals, body, and budget, in minutes.

Take the quiz →