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Calcium D-Glucarate

Detox · hormone clearance

Moderate evidenceVegan150 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Calcium D-Glucarate: Detox · hormone clearance. A compound that supports the body's natural clearance of excess hormones and toxins through the liver's glucuronidation pathway. Standard dose 500-1,000 mg, taken in the morning, about $18/month. Evidence rating: moderate evidence.

Where to buy

NOW Foods Calcium D-Glucarate
Recommended
NOW Foods, Calcium D-Glucarate
500-1,000 mg · Morning · ~$18/month

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NOW Foods Calcium D-GlucarateBestseller
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90 veg caps · $20 · ★ 4.7
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Source Naturals Calcium D-GlucarateBest Value
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120 tablets · $22 · ★ 4.6
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Thorne Calcium D-GlucaratePremium
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90 capsules · $30 · ★ 4.7
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Jarrow Formulas Calcium D-GlucaratePremium
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90 capsules · $24 · ★ 4.6
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What is Calcium D-Glucarate?

Calcium D-glucarate is the calcium salt of D-glucaric acid, a substance found in fruits and vegetables. In the body it slows an enzyme (beta-glucuronidase) that would otherwise recycle substances the liver has tagged for removal, which in theory supports clearance of excess estrogen and certain waste products through the glucuronidation detox pathway. The concept is well described in laboratory and animal work, while direct human outcome trials are still limited, so it is best framed as a supportive, emerging option rather than proven. Because it can speed the clearance of some drugs, anyone on prescription medication should check with a clinician or pharmacist. Typical use is 500 to 1000 mg daily.

A compound that supports the body's natural clearance of excess hormones and toxins through the liver's glucuronidation pathway.

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Common questions

What is Calcium D-Glucarate?
Calcium D-glucarate is the calcium salt of D-glucaric acid, a substance found in fruits and vegetables. In the body it slows an enzyme (beta-glucuronidase) that would otherwise recycle substances the liver has tagged for removal, which in theory supports clearance of excess estrogen and certain waste products through the glucuronidation detox pathway. The concept is well described in laboratory and animal work, while direct human outcome trials are still limited, so it is best framed as a supportive, emerging option rather than proven. Because it can speed the clearance of some drugs, anyone on prescription medication should check with a clinician or pharmacist. Typical use is 500 to 1000 mg daily.
What is Calcium D-Glucarate used for?
Detox · hormone clearance. A compound that supports the body's natural clearance of excess hormones and toxins through the liver's glucuronidation pathway.
What is the standard dose of Calcium D-Glucarate?
500-1,000 mg, typically taken in the morning. Approximate cost is $18 per month.
Who should avoid Calcium D-Glucarate?
Use extra caution, and speak to a clinician first, if you are taking prescription medication.
How strong is the evidence for Calcium D-Glucarate?
Moderate evidence for its primary uses. See the full study list on the research page.

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