Home/Ingredients/Ceramides (Ceramosides)
SPECIALTY

Ceramides (Ceramosides)

Skin barrier · hydration · wrinkle support

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Ceramides: Skin barrier · hydration · wrinkle support. Wheat-derived phytoceramides restore the skin's lipid barrier from within. Reduce trans-epidermal water loss. Standard dose 30 mg, taken in the morning, about $32/month. Evidence rating: moderate evidence.

What is Ceramides?

Ceramides are lipid molecules that form roughly 50% of the skin's outermost barrier (stratum corneum). Production declines with age and UV exposure, leading to dryness, wrinkles, and increased trans-epidermal water loss. Oral phytoceramides, typically derived from wheat (Ceramosides) or rice, have been shown in placebo-controlled trials to improve skin hydration, reduce visible wrinkles, and restore skin barrier function within 8-12 weeks. The Ceramosides form is the most-studied at 30 mg per day. Note: wheat-derived forms are not gluten-free.

WHY IT MATTERS

Wheat-derived phytoceramides restore the skin's lipid barrier from within. Reduce trans-epidermal water loss.

Natural food sources

Where possible, get Ceramides from whole foods first. Common dietary sources include:

WheatRiceSweet potatoSoybeansDairy

Where to buy

Life Extension Skin Restoring Ceramides
RECOMMENDED
Life Extension, Ceramides
30 mg · Morning · ~$32/month

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Common questions

What is Ceramides?
Ceramides are lipid molecules that form roughly 50% of the skin's outermost barrier (stratum corneum). Production declines with age and UV exposure, leading to dryness, wrinkles, and increased trans-epidermal water loss. Oral phytoceramides, typically derived from wheat (Ceramosides) or rice, have been shown in placebo-controlled trials to improve skin hydration, reduce visible wrinkles, and restore skin barrier function within 8-12 weeks. The Ceramosides form is the most-studied at 30 mg per day. Note: wheat-derived forms are not gluten-free.
What is Ceramides used for?
Skin barrier · hydration · wrinkle support. Wheat-derived phytoceramides restore the skin's lipid barrier from within. Reduce trans-epidermal water loss.
What is the standard dose of Ceramides?
30 mg, typically taken in the morning. Approximate cost is $32 per month.
Who should avoid Ceramides?
Use extra caution, and speak to a clinician first, if you are gluten-allergy.
How strong is the evidence for Ceramides?
Moderate evidence for its primary uses. See the full study list on the research page.

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