Ingredients · Collagen Peptides · Research
Clinical research

What does the research say about Collagen Peptides?

strong evidence

Hydrolysed collagen peptides survive digestion and reach connective tissue, where they stimulate fibroblast activity. The strongest evidence is for skin and joint outcomes.

Best-evidenced use cases
  • Skin elasticity and hydration
  • Mild osteoarthritis joint comfort
  • Athletic recovery (tendons, ligaments)
  • Nail strength
  • Post-injury connective tissue support

4 key studies

Search PubMed for more
  • 01RCT2019Journal of Drugs in Dermatology

    Oral collagen peptides and skin parameters

    Choi et al.
    Sample
    64 women, ages 40-60
    Dose
    1 g/day collagen peptide
    Duration
    12 weeks
    Key finding

    Collagen supplementation significantly improved skin elasticity and hydration vs placebo. Effects were measurable at 4 weeks and continued growing through 12.

    Read on PubMed
  • 02Systematic Review2019International Orthopaedics

    Collagen hydrolysate and joint pain: systematic review

    García-Coronado et al.
    Sample
    5 RCTs · ~519 patients
    Dose
    10 g/day
    Duration
    ≥6 months
    Key finding

    Hydrolysed collagen significantly reduced joint pain in osteoarthritis patients vs placebo. Effect sizes were comparable to glucosamine.

    Read on PubMed
  • 03RCT2008Current Medical Research and Opinion

    Collagen supplementation in athletes with activity-related joint pain

    Clark et al.
    Sample
    147 athletes
    Dose
    10 g/day collagen hydrolysate
    Duration
    24 weeks
    Key finding

    Collagen significantly reduced joint pain during activity, at rest, and following exercise vs placebo.

    Read on PubMed
  • 04Pilot RCT2017Journal of Cosmetic Dermatology

    Effects of collagen peptides on nail growth and brittleness

    Hexsel et al.
    Sample
    25 women with brittle nails
    Dose
    2.5 g/day
    Duration
    24 weeks
    Key finding

    Collagen produced a 12% increase in nail growth rate, 42% decrease in broken nails, and 64% improvement in clinical symptoms.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.