Glycine is a calming amino acid that lowers core body temperature and acts on NMDA receptors. Best-evidenced for improving sleep quality at 3 g doses before bed.
Glycine before bed significantly improved subjective sleep quality, reduced daytime sleepiness, and improved memory performance the following day.
Glycine increases blood flow to extremities, lowering core body temperature, the mechanism behind its sleep-onset effect.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.