β-hydroxy β-methylbutyrate is the leucine metabolite that signals muscle preservation. Most effective in catabolic states, older adults, illness, bed rest, calorie deficit.
HMB significantly preserved lean body mass in older adults, with the largest effects in those with sarcopenia or undergoing periods of inactivity.
HMB completely prevented the loss of lean leg mass during 10 days of bed rest, while placebo group lost significant muscle. Striking effect in catabolic state.
HMB enhanced training adaptations in untrained and elderly populations. Smaller effects in well-trained athletes, but useful during high-volume phases.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.