Lion's mane (Hericium erinaceus) contains hericenones and erinacines, compounds that stimulate nerve growth factor (NGF). Human evidence is most established for mild cognitive decline.
Lion's mane significantly improved cognitive function scores vs placebo. Benefits diminished after discontinuation, suggesting active mechanism rather than disease modification.
Lion's mane consumption produced significant reductions in depression, anxiety, and irritability scores vs placebo cookies.
Hericenones and erinacines from lion's mane cross the blood-brain barrier and stimulate NGF synthesis, providing a plausible mechanism for cognitive benefits.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.