Ingredients · Magnesium Glycinate · Research
Clinical research

What does the research say about Magnesium Glycinate?

strong evidence

Magnesium is involved in over 300 enzyme reactions and is one of the most-deficient nutrients globally. Glycinate is the most-evidenced form for sleep, stress, and long-term repletion.

Best-evidenced use cases
  • Sleep onset and depth
  • Stress and anxiety reduction
  • Muscle cramps / restless legs
  • Long-term magnesium repletion without GI side effects
  • Blood pressure modulation

4 key studies

Search PubMed for more
  • 01RCT2012Journal of Research in Medical Sciences

    Magnesium supplementation for insomnia in elderly subjects

    Abbasi et al.
    Sample
    46 older adults with insomnia
    Dose
    500 mg/day elemental Mg
    Duration
    8 weeks
    Key finding

    Magnesium significantly improved sleep efficiency, sleep time, sleep onset latency, and morning serum cortisol vs placebo.

    Read on PubMed
  • 02Systematic Review2017Nutrients

    Magnesium status and anxiety: systematic review

    Boyle et al.
    Sample
    18 studies pooled
    Dose
    Various
    Duration
    Varied
    Key finding

    Subjective anxiety improvements were consistently observed across magnesium supplementation trials, especially in subjects with low baseline status.

    Read on PubMed
  • 03Meta-analysis2007Journal of Internal Medicine

    Magnesium intake and risk of type 2 diabetes

    Larsson & Wolk
    Sample
    286,668 participants
    Dose
    Dietary
    Duration
    4-18 year follow-up
    Key finding

    Each 100 mg/day increase in magnesium intake reduced type 2 diabetes risk by 15%.

    Read on PubMed
  • 04Meta-analysis2016Hypertension

    Magnesium and blood pressure

    Zhang et al.
    Sample
    34 RCTs · 2,028 participants
    Dose
    Median 368 mg/day
    Duration
    Median 3 months
    Key finding

    Magnesium supplementation reduced systolic BP by 2.00 mmHg and diastolic by 1.78 mmHg, with stronger effects at higher doses.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.