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JOINT & CONNECTIVE TISSUE

MSM (Methylsulfonylmethane)

Joint comfort · skin · post-workout

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

MSM: Joint comfort · skin · post-workout. Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training. Standard dose 3000 mg, taken in the morning, about $15/month. Evidence rating: moderate evidence.

What is MSM?

Methylsulfonylmethane (MSM) is an organic sulfur compound that provides bioavailable sulfur, an essential building block of joint cartilage, collagen, keratin, and the body's own antioxidant glutathione. Clinical research supports MSM for joint comfort and stiffness in mild osteoarthritis, with effects often appearing within 4-6 weeks. Athletes also use it for post-workout muscle soreness and recovery. The OptiMSM brand is the most-studied purified form. Typical doses range from 1,500-3,000 mg per day, in divided doses with meals. Higher doses (up to 6 g) have been studied safely over months in clinical trials.

WHY IT MATTERS

Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training.

Where to buy

Doctor's Best MSM Powder with OptiMSM
RECOMMENDED
Doctor's Best, MSM
3000 mg · Morning · ~$15/month

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Best for your goal

Interactions

Other joint & connective tissue

Collagen Peptides
Skin · hair · nails · joints
Glucosamine + Chondroitin + MSM
Cartilage · joint comfort
Boswellia (AKBA-Enhanced)
Joint comfort · inflammation modulation
Hyaluronic Acid (Oral)
Skin hydration · joint lubrication

Common questions

What is MSM?
Methylsulfonylmethane (MSM) is an organic sulfur compound that provides bioavailable sulfur, an essential building block of joint cartilage, collagen, keratin, and the body's own antioxidant glutathione. Clinical research supports MSM for joint comfort and stiffness in mild osteoarthritis, with effects often appearing within 4-6 weeks. Athletes also use it for post-workout muscle soreness and recovery. The OptiMSM brand is the most-studied purified form. Typical doses range from 1,500-3,000 mg per day, in divided doses with meals. Higher doses (up to 6 g) have been studied safely over months in clinical trials.
What is MSM used for?
Joint comfort · skin · post-workout. Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training.
What is the standard dose of MSM?
3000 mg, typically taken in the morning. Approximate cost is $15 per month.
How strong is the evidence for MSM?
Moderate evidence for its primary uses. See the full study list on the research page.

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