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MSM (Methylsulfonylmethane)

Joint comfort · skin · post-workout

Moderate evidenceVegan1,061 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

MSM: Joint comfort · skin · post-workout. Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training. Standard dose 3000 mg, taken in the morning, about $15/month. Evidence rating: moderate evidence.

Where to buy

Doctor's Best MSM Powder with OptiMSM
Recommended
Doctor's Best, MSM
3000 mg · Morning · ~$15/month

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All product options

Doctor's Best MSM Powder with OptiMSMBestseller
MSM Powder with OptiMSM
Doctor's Best
250 g · $15 · ★ 4.8
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Nutricost MSM 1000 mgBest Value
MSM 1000 mg
Nutricost
240 caps · $14 · ★ 4.5
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Swanson MSM 1000 mgPremium
MSM 1000 mg
Swanson
240 caps · $11 · ★ 4.5
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Doctor's Best MSM with OptiMSMBest Value
MSM with OptiMSM
Doctor's Best
180 veg caps · $16 · ★ 4.8
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NOW Foods MSM 1000 mgPremium
MSM 1000 mg
NOW Foods
240 veg caps · $18 · ★ 4.8
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What is MSM?

Methylsulfonylmethane (MSM) is an organic sulfur compound that provides bioavailable sulfur, an essential building block of joint cartilage, collagen, keratin, and the body's own antioxidant glutathione. Clinical research supports MSM for joint comfort and stiffness in mild osteoarthritis, with effects often appearing within 4-6 weeks. Athletes also use it for post-workout muscle soreness and recovery. The OptiMSM brand is the most-studied purified form. Typical doses range from 1,500-3,000 mg per day, in divided doses with meals. Higher doses (up to 6 g) have been studied safely over months in clinical trials.

Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training.

Best for your goal

Interactions

Other joint & connective tissue

Collagen Peptides
Skin · hair · nails · joints
Glucosamine + Chondroitin + MSM
Cartilage · joint comfort
Boswellia (AKBA-Enhanced)
Joint comfort · inflammation modulation
Hyaluronic Acid (Oral)
Skin hydration · joint lubrication

Common questions

What is MSM?
Methylsulfonylmethane (MSM) is an organic sulfur compound that provides bioavailable sulfur, an essential building block of joint cartilage, collagen, keratin, and the body's own antioxidant glutathione. Clinical research supports MSM for joint comfort and stiffness in mild osteoarthritis, with effects often appearing within 4-6 weeks. Athletes also use it for post-workout muscle soreness and recovery. The OptiMSM brand is the most-studied purified form. Typical doses range from 1,500-3,000 mg per day, in divided doses with meals. Higher doses (up to 6 g) have been studied safely over months in clinical trials.
What is MSM used for?
Joint comfort · skin · post-workout. Bioavailable sulfur compound that supports joint comfort, connective tissue, and recovery from intense training.
What is the standard dose of MSM?
3000 mg, typically taken in the morning. Approximate cost is $15 per month.
How strong is the evidence for MSM?
Moderate evidence for its primary uses. See the full study list on the research page.

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