Ingredients · Rhodiola Rosea · Research
Clinical research

What does the research say about Rhodiola Rosea?

moderate evidence

Rhodiola rosea is the most-studied energising adaptogen. Standardized extracts (3% rosavins, 1% salidrosides) show consistent effects on mental fatigue and stress endurance.

Best-evidenced use cases
  • Mental fatigue and burnout
  • Stress-induced low mood
  • Endurance performance under fatigue
  • Exam/work performance under pressure
  • Mild depressive symptoms

3 key studies

Search PubMed for more
  • 01RCT2000Phytomedicine

    Rhodiola rosea for mental fatigue in physicians

    Darbinyan et al.
    Sample
    56 physicians on night duty
    Dose
    170 mg/day standardized extract
    Duration
    2 weeks
    Key finding

    Rhodiola significantly reduced mental fatigue and improved cognitive performance vs placebo in stressed working adults.

    Read on PubMed
  • 02Systematic Review2018International Journal of Psychiatry in Clinical Practice

    Rhodiola rosea in chronic stress: systematic review

    Anghelescu et al.
    Sample
    11 RCTs
    Dose
    200-680 mg/day
    Duration
    4-12 weeks
    Key finding

    Rhodiola consistently reduced symptoms of stress, fatigue, and exhaustion across trials, with a favourable safety profile.

    Read on PubMed
  • 03RCT2015Phytomedicine

    Rhodiola in mild-to-moderate depression

    Mao et al.
    Sample
    57 adults with mild-to-moderate depression
    Dose
    340-680 mg/day
    Duration
    12 weeks
    Key finding

    Rhodiola produced clinically meaningful antidepressant effects, smaller than sertraline but with significantly fewer side effects.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.