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Serrapeptase

Sinus · swelling · recovery

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 5 Jun 2026
Last reviewed: May 30, 2026
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Serrapeptase: Sinus · swelling · recovery. A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery. Standard dose 40,000-120,000 SPU, taken in the morning, about $16/month. Evidence rating: moderate evidence.

Where to buy

DOCTOR'SBESTSerrapeptase 40,000 SP…90 VEG CAPSDIETARY SUPP.
RECOMMENDED
Doctor's Best, Serrapeptase
40,000-120,000 SPU · Morning · ~$16/month

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All product options

DOCTOR'SBESTSerrapeptase 40,000 SP…90 VEG CAPSDIETARY SUPP.BESTSELLER
Serrapeptase 40,000 SPU
Doctor's Best
90 veg caps · $17 · ★ 4.6
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NOWFOODSSerrapeptase60 VEG CAPSDIETARY SUPP.BEST VALUE
Serrapeptase
NOW Foods
60 veg caps · $14 · ★ 4.6
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ARTHURANDREWSerretia (Serrapeptase…90 CAPSULESDIETARY SUPP.PREMIUM
Serretia (Serrapeptase)
Arthur Andrew
90 capsules · $40 · ★ 4.7
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SOURCENATURALSSerrapeptase60 TABLETSDIETARY SUPP.PREMIUM
Serrapeptase
Source Naturals
60 tablets · $16 · ★ 4.5
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What is Serrapeptase?

Serrapeptase is a protein-digesting enzyme first identified in silkworm-associated bacteria and now produced by fermentation. Taken on an empty stomach so it reaches the bloodstream intact, it is used to help thin mucus and ease sinus and respiratory congestion, and traditionally for swelling and post-injury comfort. Clinical evidence is mixed and mostly from small studies, so it is fair to call it promising rather than proven, and quality varies widely, with potency measured in SPU or activity units. It has mild blood-thinning potential, so it should be paused before surgery and used cautiously with anticoagulants. Typical servings provide 40,000 to 120,000 units away from food.

WHY IT MATTERS

A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery.

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Common questions

What is Serrapeptase?
Serrapeptase is a protein-digesting enzyme first identified in silkworm-associated bacteria and now produced by fermentation. Taken on an empty stomach so it reaches the bloodstream intact, it is used to help thin mucus and ease sinus and respiratory congestion, and traditionally for swelling and post-injury comfort. Clinical evidence is mixed and mostly from small studies, so it is fair to call it promising rather than proven, and quality varies widely, with potency measured in SPU or activity units. It has mild blood-thinning potential, so it should be paused before surgery and used cautiously with anticoagulants. Typical servings provide 40,000 to 120,000 units away from food.
What is Serrapeptase used for?
Sinus · swelling · recovery. A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery.
What is the standard dose of Serrapeptase?
40,000-120,000 SPU, typically taken in the morning. Approximate cost is $16 per month.
Who should avoid Serrapeptase?
Use extra caution, and speak to a clinician first, if you are on blood thinners.
How strong is the evidence for Serrapeptase?
Moderate evidence for its primary uses. See the full study list on the research page.

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