Home/Ingredients/Serrapeptase

Serrapeptase

Sinus · swelling · recovery

Moderate evidenceVegan16 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Serrapeptase: Sinus · swelling · recovery. A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery. Standard dose 40,000-120,000 SPU, taken in the morning, about $16/month. Evidence rating: moderate evidence.

Where to buy

California Gold Nutrition Serrapeptase, 120,000 SPU
Recommended
Doctor's Best, Serrapeptase
40,000-120,000 SPU · Morning · ~$16/month

suppdoc.io is an affiliate. Links may earn us a commission at no extra cost to you.

All product options

California Gold Nutrition Serrapeptase, 120,000 SPUBestseller
Serrapeptase, 120,000 SPU
California Gold Nutrition
180 veg capsules · $30 · ★ 4.7
Buy on iHerb →
Doctor's Best Serrapeptase 40,000 SPUBestseller
Serrapeptase 40,000 SPU
Doctor's Best
90 veg caps · $17 · ★ 4.6
Buy on iHerb →
NOW Foods SerrapeptaseBest Value
Serrapeptase
NOW Foods
60 veg caps · $14 · ★ 4.6
Buy on iHerb →
Arthur Andrew Serretia (Serrapeptase)Premium
Serretia (Serrapeptase)
Arthur Andrew
90 capsules · $40 · ★ 4.7
Buy on iHerb →
Source Naturals SerrapeptasePremium
Serrapeptase
Source Naturals
60 tablets · $16 · ★ 4.5
Buy on iHerb →

What is Serrapeptase?

Serrapeptase is a protein-digesting enzyme first identified in silkworm-associated bacteria and now produced by fermentation. Taken on an empty stomach so it reaches the bloodstream intact, it is used to help thin mucus and ease sinus and respiratory congestion, and traditionally for swelling and post-injury comfort. Clinical evidence is mixed and mostly from small studies, so it is fair to call it promising rather than proven, and quality varies widely, with potency measured in SPU or activity units. It has mild blood-thinning potential, so it should be paused before surgery and used cautiously with anticoagulants. Typical servings provide 40,000 to 120,000 units away from food.

A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery.

Best for your goal

Other specialty

Elderberry Extract
Immune support · seasonal
Berberine HCl
Blood sugar · metabolic health · gut
Milk Thistle (Silymarin)
Liver support · antioxidant
ZMA (Zn + Mg + B6)
Sleep · recovery · testosterone (male)

Common questions

What is Serrapeptase?
Serrapeptase is a protein-digesting enzyme first identified in silkworm-associated bacteria and now produced by fermentation. Taken on an empty stomach so it reaches the bloodstream intact, it is used to help thin mucus and ease sinus and respiratory congestion, and traditionally for swelling and post-injury comfort. Clinical evidence is mixed and mostly from small studies, so it is fair to call it promising rather than proven, and quality varies widely, with potency measured in SPU or activity units. It has mild blood-thinning potential, so it should be paused before surgery and used cautiously with anticoagulants. Typical servings provide 40,000 to 120,000 units away from food.
What is Serrapeptase used for?
Sinus · swelling · recovery. A proteolytic enzyme taken on an empty stomach, used to support sinus comfort, swelling, and recovery.
What is the standard dose of Serrapeptase?
40,000-120,000 SPU, typically taken in the morning. Approximate cost is $16 per month.
Who should avoid Serrapeptase?
Use extra caution, and speak to a clinician first, if you are on blood thinners.
How strong is the evidence for Serrapeptase?
Moderate evidence for its primary uses. See the full study list on the research page.

Not sure if Serrapeptase is right for you?

Take our quiz. We'll compose a personalised stack that fits your goals, body, and budget, in minutes.

Take the quiz →