Home/Ingredients/Spermidine (Wheat Germ Extract)
SPECIALTY

Spermidine (Wheat Germ Extract)

Autophagy · cellular renewal · longevity

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Spermidine: Autophagy · cellular renewal · longevity. Triggers autophagy, the cellular self-cleaning process. Higher dietary spermidine is linked to longer lifespan. Standard dose 10 mg, taken in the morning, about $28/month. Evidence rating: moderate evidence.

What is Spermidine?

Spermidine is a naturally occurring polyamine first discovered in semen (hence the name) but present in every living cell. It is a potent inducer of autophagy, the cellular process of breaking down and recycling damaged components. Large observational studies link higher dietary spermidine intake (from foods like aged cheese, wheat germ, mushrooms, and natto) to lower all-cause mortality and reduced cardiovascular risk. Preclinical research shows lifespan extension across yeast, flies, worms, and mice. Supplemental doses of 1-10 mg per day match the upper range of dietary intake in long-lived populations.

WHY IT MATTERS

Triggers autophagy, the cellular self-cleaning process. Higher dietary spermidine is linked to longer lifespan.

Natural food sources

Where possible, get Spermidine from whole foods first. Common dietary sources include:

Wheat germNattoAged cheeseMushroomsSoybeans

Where to buy

Double Wood Spermidine 10mg
RECOMMENDED
Double Wood, Spermidine
10 mg · Morning · ~$28/month

suppdoc.io is an affiliate. Links may earn us a commission at no extra cost to you.

Best for your goal

Interactions

Other specialty

Elderberry Extract
Immune support · seasonal
Berberine HCl
Blood sugar · metabolic health · gut
Milk Thistle (Silymarin)
Liver support · antioxidant
ZMA (Zn + Mg + B6)
Sleep · recovery · testosterone (male)

Common questions

What is Spermidine?
Spermidine is a naturally occurring polyamine first discovered in semen (hence the name) but present in every living cell. It is a potent inducer of autophagy, the cellular process of breaking down and recycling damaged components. Large observational studies link higher dietary spermidine intake (from foods like aged cheese, wheat germ, mushrooms, and natto) to lower all-cause mortality and reduced cardiovascular risk. Preclinical research shows lifespan extension across yeast, flies, worms, and mice. Supplemental doses of 1-10 mg per day match the upper range of dietary intake in long-lived populations.
What is Spermidine used for?
Autophagy · cellular renewal · longevity. Triggers autophagy, the cellular self-cleaning process. Higher dietary spermidine is linked to longer lifespan.
What is the standard dose of Spermidine?
10 mg, typically taken in the morning. Approximate cost is $28 per month.
How strong is the evidence for Spermidine?
Moderate evidence for its primary uses. See the full study list on the research page.

Not sure if Spermidine is right for you?

Take our quiz. We'll compose a personalised stack that fits your goals, body, and budget, in minutes.

Take the quiz →