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SPECIALTY

TUDCA (Tauroursodeoxycholic Acid)

Liver · bile flow · cellular stress

MODERATE EVIDENCEREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

TUDCA: Liver · bile flow · cellular stress. Bile acid that supports liver detox, bile flow, and protects cells against ER stress. Used by athletes alongside hormonal compounds. Standard dose 500 mg, taken in the evening, about $32/month. Evidence rating: moderate evidence.

What is TUDCA?

Tauroursodeoxycholic acid (TUDCA) is a bile acid naturally produced in trace amounts by gut bacteria from ursodeoxycholic acid (UDCA), a compound originally isolated from bear bile and used in human medicine for over a century to treat gallstones and certain liver conditions. TUDCA's standout property is its protective effect against endoplasmic reticulum (ER) stress, a state of cellular protein-folding overload implicated in liver disease, neurodegeneration, and diabetes. Supplementation supports liver function, healthy bile flow, eye health, and is often used as cycle support by athletes taking hepatotoxic compounds. Standard dose is 250-1,000 mg per day. Most TUDCA is bovine-derived; vegan synthetic options exist but are less common.

WHY IT MATTERS

Bile acid that supports liver detox, bile flow, and protects cells against ER stress. Used by athletes alongside hormonal compounds.

Where to buy

Nutricost TUDCA 500mg
RECOMMENDED
Nutricost, TUDCA
500 mg · Evening · ~$32/month

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Common questions

What is TUDCA?
Tauroursodeoxycholic acid (TUDCA) is a bile acid naturally produced in trace amounts by gut bacteria from ursodeoxycholic acid (UDCA), a compound originally isolated from bear bile and used in human medicine for over a century to treat gallstones and certain liver conditions. TUDCA's standout property is its protective effect against endoplasmic reticulum (ER) stress, a state of cellular protein-folding overload implicated in liver disease, neurodegeneration, and diabetes. Supplementation supports liver function, healthy bile flow, eye health, and is often used as cycle support by athletes taking hepatotoxic compounds. Standard dose is 250-1,000 mg per day. Most TUDCA is bovine-derived; vegan synthetic options exist but are less common.
What is TUDCA used for?
Liver · bile flow · cellular stress. Bile acid that supports liver detox, bile flow, and protects cells against ER stress. Used by athletes alongside hormonal compounds.
What is the standard dose of TUDCA?
500 mg, typically taken in the evening. Approximate cost is $32 per month.
Who should avoid TUDCA?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing.
How strong is the evidence for TUDCA?
Moderate evidence for its primary uses. See the full study list on the research page.

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