Agmatine Sulfate
Pumps · mood · neuroprotection
Agmatine Sulfate: Pumps · mood · neuroprotection. A metabolite of arginine that boosts nitric-oxide-driven pumps and modulates mood and pain pathways in the brain. Standard dose 500-1,000 mg, taken in the pre-workout, about $22/month. Evidence rating: moderate evidence.
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What is Agmatine Sulfate?
Agmatine sulfate is made from the amino acid arginine and acts on several systems at once. In the gym it supports vasodilation and longer-lasting muscle pumps by influencing nitric oxide. In the brain it is a neuromodulator studied for mood, stress resilience, and the dampening of chronic pain signaling, with promising but still early human data. Pre-workout doses of 0.5 to 1 g are common, and some use a similar dose daily for mood. It is generally well tolerated, though it can lower blood pressure, so start low if you are prone to lightheadedness.
A metabolite of arginine that boosts nitric-oxide-driven pumps and modulates mood and pain pathways in the brain.
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