Ingredients · Alpha-GPC · Research
Clinical research

What does the research say about Alpha-GPC?

strong evidence

Alpha-GPC is the most bioavailable choline source for the brain. Established for cognitive support in mild dementia; growing evidence for athletic performance.

Best-evidenced use cases
  • Mild cognitive impairment (clinical use)
  • Acute focus and reaction time
  • Power output before training
  • Recovery from stroke (clinical)

2 key studies

Search PubMed for more
  • 01RCT2003Clinical Therapeutics

    Alpha-GPC and mild-to-moderate Alzheimer's

    De Jesus Moreno
    Sample
    261 mild-moderate Alzheimer's patients
    Dose
    1,200 mg/day
    Duration
    180 days
    Key finding

    Alpha-GPC produced significant improvements in cognitive function tests vs placebo and was well-tolerated over 6 months.

    Read on PubMed
  • 02RCT2015Journal of the International Society of Sports Nutrition

    Alpha-GPC and exercise performance

    Bellar et al.
    Sample
    13 healthy adults
    Dose
    600 mg pre-exercise
    Duration
    Single dose
    Key finding

    Alpha-GPC significantly increased lower-body power output and peak bench press force vs placebo in resistance-trained individuals.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

Make it actionable

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The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.