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Alpha-GPC

Acetylcholine · power output · focus

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Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Alpha-GPC: Acetylcholine · power output · focus. The most bioavailable choline source. Boosts acetylcholine for sharp focus and may modestly enhance growth hormone before training. Standard dose 300 mg, taken in the morning, about $22/month. Evidence rating: strong evidence.

What is Alpha-GPC?

Alpha-GPC (L-alpha-glycerylphosphorylcholine) is among the most bioavailable forms of choline, crossing the blood-brain barrier efficiently and serving as a direct precursor to the neurotransmitter acetylcholine. Acetylcholine governs focus, learning speed, memory recall, and the brain-muscle connection during movement. Clinical studies have shown benefits for cognitive function in healthy adults, as well as modest improvements in power output and growth hormone release when taken before exercise. Athletes and knowledge workers commonly use 300-600 mg per day. Combining Alpha-GPC with caffeine can produce a noticeably 'clean' stimulant effect without the typical jitter.

WHY IT MATTERS

The most bioavailable choline source. Boosts acetylcholine for sharp focus and may modestly enhance growth hormone before training.

Where to buy

NOW Foods Alpha GPC 300mg
RECOMMENDED
NOW Foods, Alpha-GPC
300 mg · Morning · ~$22/month

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Common questions

What is Alpha-GPC?
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is among the most bioavailable forms of choline, crossing the blood-brain barrier efficiently and serving as a direct precursor to the neurotransmitter acetylcholine. Acetylcholine governs focus, learning speed, memory recall, and the brain-muscle connection during movement. Clinical studies have shown benefits for cognitive function in healthy adults, as well as modest improvements in power output and growth hormone release when taken before exercise. Athletes and knowledge workers commonly use 300-600 mg per day. Combining Alpha-GPC with caffeine can produce a noticeably 'clean' stimulant effect without the typical jitter.
What is Alpha-GPC used for?
Acetylcholine · power output · focus. The most bioavailable choline source. Boosts acetylcholine for sharp focus and may modestly enhance growth hormone before training.
What is the standard dose of Alpha-GPC?
300 mg, typically taken in the morning. Approximate cost is $22 per month.
How strong is the evidence for Alpha-GPC?
Strong evidence for its primary uses. See the full study list on the research page.

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