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NOOTROPICS

Citicoline (CDP-Choline)

Focus · attention · brain energy

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Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Citicoline: Focus · attention · brain energy. Choline source that converts into both phosphatidylcholine (membranes) and acetylcholine (signaling). Sharper than plain choline. Standard dose 250 mg, taken in the morning, about $26/month. Evidence rating: strong evidence.

What is Citicoline?

Citicoline, also known as CDP-choline, is a naturally occurring compound that provides both choline (a precursor to the neurotransmitter acetylcholine) and cytidine (a precursor to uridine, important for synaptic plasticity). The Cognizin branded form has been used in placebo-controlled trials showing improvements in attention, focus, and information processing speed in healthy adults. Citicoline also supports phosphatidylcholine synthesis in neuronal membranes, contributing to long-term brain structural integrity. Standard daily doses range from 250-500 mg in the morning. It is one of the few nootropics with both acute and cumulative effects.

WHY IT MATTERS

Choline source that converts into both phosphatidylcholine (membranes) and acetylcholine (signaling). Sharper than plain choline.

Where to buy

Jarrow Formulas Citicoline (CDP-Choline) 250mg
RECOMMENDED
Cognizin, Citicoline
250 mg · Morning · ~$26/month

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Stacks that include Citicoline

✦
The Focus Stack
Sharper mind, calmer attention.

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Interactions

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Common questions

What is Citicoline?
Citicoline, also known as CDP-choline, is a naturally occurring compound that provides both choline (a precursor to the neurotransmitter acetylcholine) and cytidine (a precursor to uridine, important for synaptic plasticity). The Cognizin branded form has been used in placebo-controlled trials showing improvements in attention, focus, and information processing speed in healthy adults. Citicoline also supports phosphatidylcholine synthesis in neuronal membranes, contributing to long-term brain structural integrity. Standard daily doses range from 250-500 mg in the morning. It is one of the few nootropics with both acute and cumulative effects.
What is Citicoline used for?
Focus · attention · brain energy. Choline source that converts into both phosphatidylcholine (membranes) and acetylcholine (signaling). Sharper than plain choline.
What is the standard dose of Citicoline?
250 mg, typically taken in the morning. Approximate cost is $26 per month.
How strong is the evidence for Citicoline?
Strong evidence for its primary uses. See the full study list on the research page.

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