Vitamin D3 is one of the most-studied supplements in human history, over 90,000 published papers. The combination with K2 directs supplemental calcium into bones and away from arteries.
Vitamin D3 (not D2) supplementation reduced all-cause mortality by 6% (RR 0.94). The effect was consistent across age groups.
Daily/weekly vitamin D reduced acute respiratory infection risk (OR 0.81). Strongest in those most deficient at baseline.
MK-7 supplementation significantly reduced age-related loss in vertebral and hip bone mineral content vs placebo.
Vitamin D supplementation produced significant improvements in depressive symptoms vs placebo (SMD -0.49) in adults with low baseline status.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.