Ingredients · Iron Bisglycinate · Research
Clinical research

What does the research say about Iron Bisglycinate?

very strong evidence

Iron deficiency (with or without anaemia) is the world's most common nutrient deficiency, especially in menstruating women and athletes. Supplementation should follow ferritin testing.

Best-evidenced use cases
  • Confirmed low ferritin (test first!)
  • Heavy menstrual bleeding
  • Endurance athletes
  • Pregnancy
  • Restless legs from low iron

3 key studies

Search PubMed for more
  • 01RCT2003BMJ

    Iron supplementation in iron-deficient non-anaemic women

    Verdon et al.
    Sample
    144 women with unexplained fatigue + low ferritin
    Dose
    80 mg/day ferrous sulfate
    Duration
    4 weeks
    Key finding

    Iron significantly reduced fatigue scores in non-anaemic women with low ferritin (≤50 ng/mL), the first trial supporting low-ferritin treatment without anaemia.

    Read on PubMed
  • 02RCT2017The Lancet Haematology

    Alternate-day iron supplementation improves absorption

    Stoffel et al.
    Sample
    40 iron-deficient women
    Dose
    60-120 mg ferrous sulfate
    Duration
    -
    Key finding

    Alternate-day dosing (rather than daily) significantly improved iron absorption and reduced GI side effects. This changed clinical practice globally.

    Read on PubMed
  • 03Systematic Review2018Sleep Medicine

    Iron and restless legs syndrome

    Allen et al.
    Sample
    Pooled clinical evidence
    Dose
    65 mg/day with vitamin C
    Duration
    12+ weeks
    Key finding

    Iron supplementation significantly reduced restless legs severity in patients with serum ferritin <75 ng/mL.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.