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Lithium Orotate (Low-Dose)

Mood stability · neuroprotection

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Lithium Orotate: Mood stability · neuroprotection. Microdose lithium, far below pharmaceutical levels. May support stable mood and neurological resilience. Not for treating diagnosed mood disorders. Standard dose 5 mg elemental lithium, taken in the morning, about $16/month. Evidence rating: moderate evidence.

What is Lithium Orotate?

Lithium is a naturally occurring trace mineral found in drinking water, vegetables, and grains. While high-dose lithium carbonate (600-1,800 mg) is a prescription medication for bipolar disorder, micro-dose lithium orotate (typically 5-20 mg of elemental lithium) supplies just a fraction of that amount, closer to the range found in mineral-rich drinking water. Epidemiological studies have observed that populations with higher lithium content in their water supply show lower rates of mood disorders, suicide, and dementia. Research suggests microdose lithium may support neuroprotection, mood stability, and cellular repair pathways. People with diagnosed mood disorders or on lithium medication should not use this without clinician supervision.

WHY IT MATTERS

Microdose lithium, far below pharmaceutical levels. May support stable mood and neurological resilience. Not for treating diagnosed mood disorders.

Where to buy

Pure Encapsulations Lithium (orotate) 5mg
RECOMMENDED
Pure Encapsulations, Lithium Orotate
5 mg elemental lithium · Morning · ~$16/month

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Common questions

What is Lithium Orotate?
Lithium is a naturally occurring trace mineral found in drinking water, vegetables, and grains. While high-dose lithium carbonate (600-1,800 mg) is a prescription medication for bipolar disorder, micro-dose lithium orotate (typically 5-20 mg of elemental lithium) supplies just a fraction of that amount, closer to the range found in mineral-rich drinking water. Epidemiological studies have observed that populations with higher lithium content in their water supply show lower rates of mood disorders, suicide, and dementia. Research suggests microdose lithium may support neuroprotection, mood stability, and cellular repair pathways. People with diagnosed mood disorders or on lithium medication should not use this without clinician supervision.
What is Lithium Orotate used for?
Mood stability · neuroprotection. Microdose lithium, far below pharmaceutical levels. May support stable mood and neurological resilience. Not for treating diagnosed mood disorders.
What is the standard dose of Lithium Orotate?
5 mg elemental lithium, typically taken in the morning. Approximate cost is $16 per month.
Who should avoid Lithium Orotate?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing, bipolar disorder.
How strong is the evidence for Lithium Orotate?
Moderate evidence for its primary uses. See the full study list on the research page.

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