Chronic NMN supplementation and insulin sensitivity
NMN significantly improved muscle insulin sensitivity, muscle remodeling signaling, and aerobic capacity vs placebo.
NMN is one of the most active research areas in longevity science. Multiple recent human trials confirm safe NAD+ elevation. Functional outcomes are still being characterised, promising but not yet definitive.
NMN significantly improved muscle insulin sensitivity, muscle remodeling signaling, and aerobic capacity vs placebo.
NMN dose-dependently improved aerobic capacity (VO2 max) and ventilatory threshold in runners, first evidence of performance benefit in healthy adults.
NMN safely elevated blood NAD+ levels by ~38% and improved walking endurance and right-leg muscle function in adults 60+.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.