Ingredients · NMN · Research
Clinical research

What does the research say about NMN?

emerging evidence

NMN is one of the most active research areas in longevity science. Multiple recent human trials confirm safe NAD+ elevation. Functional outcomes are still being characterised, promising but not yet definitive.

Best-evidenced use cases
  • Restoring age-related NAD+ decline
  • Energy and endurance in adults 40+
  • Insulin sensitivity (early evidence)
  • Longevity protocols (Sinclair group)

3 key studies

Search PubMed for more
  • 01RCT2021Science

    Chronic NMN supplementation and insulin sensitivity

    Yoshino et al.
    Sample
    25 postmenopausal women with prediabetes
    Dose
    250 mg/day NMN
    Duration
    10 weeks
    Key finding

    NMN significantly improved muscle insulin sensitivity, muscle remodeling signaling, and aerobic capacity vs placebo.

    Read on PubMed
  • 02RCT2021Journal of the International Society of Sports Nutrition

    NMN and aerobic capacity / functional performance

    Liao et al.
    Sample
    48 amateur runners
    Dose
    300-1,200 mg/day NMN
    Duration
    6 weeks
    Key finding

    NMN dose-dependently improved aerobic capacity (VO2 max) and ventilatory threshold in runners, first evidence of performance benefit in healthy adults.

    Read on PubMed
  • 03RCT2022npj Aging

    Safety and NAD+ elevation in healthy older adults

    Igarashi et al.
    Sample
    108 older adults
    Dose
    250 mg/day NMN
    Duration
    12 weeks
    Key finding

    NMN safely elevated blood NAD+ levels by ~38% and improved walking endurance and right-leg muscle function in adults 60+.

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.