Home/Ingredients/NMN (Nicotinamide Mononucleotide)
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NMN (Nicotinamide Mononucleotide)

NAD+ precursor · cellular energy · longevity

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

NMN: NAD+ precursor · cellular energy · longevity. Direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and DNA repair. Levels drop ~50% by age 50. Standard dose 500 mg, taken in the morning, about $38/month. Evidence rating: moderate evidence.

What is NMN?

Nicotinamide mononucleotide (NMN) is a direct precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme present in every cell that powers mitochondrial energy production, DNA repair, and sirtuin activity. NAD+ levels decline roughly 50% between age 40 and 60, and this drop is now considered a hallmark of biological aging. Human trials with NMN at 250-900 mg/day have shown improvements in NAD+ blood levels, walking endurance, insulin sensitivity, and self-reported energy. NMN was popularized by longevity researcher Dr. David Sinclair of Harvard Medical School. The standard daily dose is 250-500 mg taken in the morning, often paired with TMG as a methyl donor.

WHY IT MATTERS

Direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and DNA repair. Levels drop ~50% by age 50.

Where to buy

Double Wood NMN 500mg
RECOMMENDED
Double Wood, NMN
500 mg · Morning · ~$38/month

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The Longevity Blueprint
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Common questions

What is NMN?
Nicotinamide mononucleotide (NMN) is a direct precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme present in every cell that powers mitochondrial energy production, DNA repair, and sirtuin activity. NAD+ levels decline roughly 50% between age 40 and 60, and this drop is now considered a hallmark of biological aging. Human trials with NMN at 250-900 mg/day have shown improvements in NAD+ blood levels, walking endurance, insulin sensitivity, and self-reported energy. NMN was popularized by longevity researcher Dr. David Sinclair of Harvard Medical School. The standard daily dose is 250-500 mg taken in the morning, often paired with TMG as a methyl donor.
What is NMN used for?
NAD+ precursor · cellular energy · longevity. Direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and DNA repair. Levels drop ~50% by age 50.
What is the standard dose of NMN?
500 mg, typically taken in the morning. Approximate cost is $38 per month.
How strong is the evidence for NMN?
Moderate evidence for its primary uses. See the full study list on the research page.

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