Ingredients · Multi-Strain Probiotic · Research
Clinical research

What does the research say about Multi-Strain Probiotic?

strong evidence

Probiotic effects are strain-specific. Generic 'probiotic' doesn't mean much, the evidence accumulates around specific strains tested for specific conditions.

Best-evidenced use cases
  • Antibiotic-associated diarrhea prevention (S. boulardii, LGG)
  • IBS symptoms (B. infantis 35624)
  • Acute infectious diarrhea (LGG)
  • Mood and anxiety (Lactobacillus helveticus + B. longum)
  • Vaginal microbiome (L. crispatus)

3 key studies

Search PubMed for more
  • 01Meta-analysis2017Cochrane Database of Systematic Reviews

    Probiotics for prevention of antibiotic-associated diarrhea

    Goldenberg et al.
    Sample
    33 RCTs · 6,352 children/adults
    Dose
    Various strains
    Duration
    During + 2 weeks post-antibiotics
    Key finding

    Probiotic supplementation reduced antibiotic-associated diarrhea risk by 60% (RR 0.40). Strongest evidence: Lactobacillus rhamnosus GG and Saccharomyces boulardii.

    Read on PubMed
  • 02Meta-analysis2018American Journal of Gastroenterology

    Probiotics in irritable bowel syndrome

    Ford et al.
    Sample
    53 RCTs · 5,545 patients
    Dose
    Various
    Duration
    ≥4 weeks
    Key finding

    Probiotics significantly improved global IBS symptoms vs placebo (RR 0.79). Bifidobacterium infantis 35624 had the strongest single-strain evidence.

    Read on PubMed
  • 03Meta-analysis2019Neuroscience & Biobehavioral Reviews

    Probiotic effects on depression and anxiety

    Liu et al.
    Sample
    34 RCTs · 2,165 participants
    Dose
    Various multi-strain
    Duration
    ≥4 weeks
    Key finding

    Probiotic supplementation produced small but significant improvements in depression and anxiety scores (SMD -0.13 and -0.31).

    Read on PubMed
How we read the research

We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.

What we don't do

We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.

Make it actionable

See Multi-Strain Probiotic in a personalised stack

The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.

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Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.