Urolithin A is one of the most rigorously researched longevity ingredients of the last decade. The Mitopure form is the only commercially-available source with published RCTs.
Urolithin A dose-dependently improved mitochondrial gene expression and muscle function biomarkers, first human evidence of mitophagy induction by an oral supplement.
Urolithin A significantly improved muscle endurance (hand grip, leg muscle) and reduced inflammatory markers vs placebo in middle-aged adults.
Urolithin A demonstrated favourable safety, improved muscle strength (~12% vs placebo), and significantly increased peak power output during exercise tests.
We prioritize randomised controlled trials and meta-analyses over single observational studies. Animal and in-vitro data are listed as "mechanistic", they suggest direction, not human effect size.
We don't cherry-pick favourable studies, omit conflicting evidence, or cite industry-funded trials without flagging the conflict of interest where known.
The research is one thing, what to take, at what dose, paired with what, is another. We compose stacks that turn the evidence into a daily routine.
Studies referenced are real published research. Summaries are paraphrased for accessibility, for exact methods and full text, click through to PubMed. Educational use only, not medical advice. Consult a qualified clinician before starting any new supplement.