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Fisetin is a polyphenol flavonoid found naturally in strawberries, apples, and onions, but in amounts far too small to deliver meaningful effects. At supplemental doses, fisetin has demonstrated senolytic activity in preclinical research, meaning it selectively triggers apoptosis in senescent ('zombie') cells that accumulate with aging and secrete inflammatory signals. Mayo Clinic researchers have launched human trials investigating fisetin for frailty, chronic kidney disease, and Alzheimer's prevention. Many longevity protocols use a 'hit-and-run' approach: 1,000 mg per day for 2 consecutive days monthly. Daily lower doses of 100-500 mg are also common.
A plant flavonoid that selectively clears senescent ('zombie') cells which accumulate with age and drive inflammation.
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