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Fisetin (Senolytic)

Senolytic · clears senescent cells · longevity

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Fisetin: Senolytic · clears senescent cells · longevity. A plant flavonoid that selectively clears senescent ('zombie') cells which accumulate with age and drive inflammation. Standard dose 500 mg, taken in the morning, about $32/month. Evidence rating: moderate evidence.

What is Fisetin?

Fisetin is a polyphenol flavonoid found naturally in strawberries, apples, and onions, but in amounts far too small to deliver meaningful effects. At supplemental doses, fisetin has demonstrated senolytic activity in preclinical research, meaning it selectively triggers apoptosis in senescent ('zombie') cells that accumulate with aging and secrete inflammatory signals. Mayo Clinic researchers have launched human trials investigating fisetin for frailty, chronic kidney disease, and Alzheimer's prevention. Many longevity protocols use a 'hit-and-run' approach: 1,000 mg per day for 2 consecutive days monthly. Daily lower doses of 100-500 mg are also common.

WHY IT MATTERS

A plant flavonoid that selectively clears senescent ('zombie') cells which accumulate with age and drive inflammation.

Natural food sources

Where possible, get Fisetin from whole foods first. Common dietary sources include:

StrawberriesApplesPersimmonsOnions

Where to buy

Double Wood Fisetin 500mg
RECOMMENDED
Double Wood, Fisetin
500 mg · Morning · ~$32/month

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Stacks that include Fisetin

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The Longevity Blueprint
The frontier protocol for slower biological aging.

Best for your goal

Interactions

Other antioxidants

Curcumin (with BioPerine)
Inflammation · joint · recovery
CoQ10 (Ubiquinol)
Cellular energy · heart
Alpha-Lipoic Acid (ALA)
Antioxidant · blood sugar · nerve health
Quercetin (with Bromelain)
Immune · allergies · circulation

Common questions

What is Fisetin?
Fisetin is a polyphenol flavonoid found naturally in strawberries, apples, and onions, but in amounts far too small to deliver meaningful effects. At supplemental doses, fisetin has demonstrated senolytic activity in preclinical research, meaning it selectively triggers apoptosis in senescent ('zombie') cells that accumulate with aging and secrete inflammatory signals. Mayo Clinic researchers have launched human trials investigating fisetin for frailty, chronic kidney disease, and Alzheimer's prevention. Many longevity protocols use a 'hit-and-run' approach: 1,000 mg per day for 2 consecutive days monthly. Daily lower doses of 100-500 mg are also common.
What is Fisetin used for?
Senolytic · clears senescent cells · longevity. A plant flavonoid that selectively clears senescent ('zombie') cells which accumulate with age and drive inflammation.
What is the standard dose of Fisetin?
500 mg, typically taken in the morning. Approximate cost is $32 per month.
How strong is the evidence for Fisetin?
Moderate evidence for its primary uses. See the full study list on the research page.

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