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ANTIOXIDANTS

Alpha-Lipoic Acid (ALA)

Antioxidant · blood sugar · nerve health

STRONG EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Alpha-Lipoic Acid: Antioxidant · blood sugar · nerve health. Universal antioxidant that works in both water- and fat-soluble compartments. Supports insulin sensitivity and nerve health. Standard dose 300 mg, taken in the morning, about $14/month. Evidence rating: strong evidence.

What is Alpha-Lipoic Acid?

Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid synthesized in the mitochondria, where it functions as a critical cofactor for energy-producing enzymes. Uniquely, ALA is soluble in both water and fat, allowing it to neutralize free radicals throughout the entire cell, earning it the title 'universal antioxidant.' It also regenerates other antioxidants including vitamins C and E, glutathione, and CoQ10. Clinical research has focused on ALA's role in supporting healthy blood sugar regulation, insulin sensitivity, and peripheral nerve health. Most studies use 300-600 mg per day, taken on an empty stomach for optimal absorption.

WHY IT MATTERS

Universal antioxidant that works in both water- and fat-soluble compartments. Supports insulin sensitivity and nerve health.

Natural food sources

Where possible, get Alpha-Lipoic Acid from whole foods first. Common dietary sources include:

Organ meats (liver, heart)SpinachBroccoliRed meat

Where to buy

Doctor's Best Alpha-Lipoic Acid 300mg
RECOMMENDED
Doctor's Best, Alpha-Lipoic Acid
300 mg · Morning · ~$14/month

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Best for your goal

Interactions

Related biomarkers

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Inflammation · joint · recovery
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Quercetin (with Bromelain)
Immune · allergies · circulation
Resveratrol (Trans)
Longevity · circulation · antioxidant

Common questions

What is Alpha-Lipoic Acid?
Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid synthesized in the mitochondria, where it functions as a critical cofactor for energy-producing enzymes. Uniquely, ALA is soluble in both water and fat, allowing it to neutralize free radicals throughout the entire cell, earning it the title 'universal antioxidant.' It also regenerates other antioxidants including vitamins C and E, glutathione, and CoQ10. Clinical research has focused on ALA's role in supporting healthy blood sugar regulation, insulin sensitivity, and peripheral nerve health. Most studies use 300-600 mg per day, taken on an empty stomach for optimal absorption.
What is Alpha-Lipoic Acid used for?
Antioxidant · blood sugar · nerve health. Universal antioxidant that works in both water- and fat-soluble compartments. Supports insulin sensitivity and nerve health.
What is the standard dose of Alpha-Lipoic Acid?
300 mg, typically taken in the morning. Approximate cost is $14 per month.
How strong is the evidence for Alpha-Lipoic Acid?
Strong evidence for its primary uses. See the full study list on the research page.

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