Best supplements for blood sugar.
Supplements with evidence for supporting healthy blood-sugar and insulin sensitivity, useful alongside diet, not instead of medical care.
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Each pick is evidence-graded · we don't sell supplements
- 1Magnesium GlycinateStrongBioavailable, gentle, non-laxative magnesium. Supports deep sleep, calms the nervous system, eases muscle tension.400 mg elemental · evening · ~$14/mo
- 2InositolStrongVitamin-like compound clinically studied for ovarian function, insulin sensitivity, anxiety, and obsessive thought patterns.2000 mg · morning · ~$22/mo
- 3Berberine HClStrongBotanical compound that activates AMPK, supports healthy blood glucose, lipid profile, and metabolic flexibility.500 mg · midday · ~$22/mo
- 4Alpha-Lipoic AcidStrongUniversal antioxidant that works in both water- and fat-soluble compartments. Supports insulin sensitivity and nerve health.300 mg · morning · ~$14/mo
- 5Chromium PicolinateModerateTrace mineral that enhances insulin signaling. May support balanced blood sugar and reduce carbohydrate cravings.200 mcg · morning · ~$8/mo
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Common questions
What is the best supplement for blood sugar?
Berberine has the strongest evidence (often compared to metformin in trials); chromium, alpha-lipoic acid, and magnesium also support glucose metabolism and insulin sensitivity.
Can I take berberine with diabetes medication?
Berberine can lower blood sugar meaningfully, so combining it with diabetes medication risks hypoglycaemia. Only do so under a clinician's supervision.
Educational use only, not medical advice. Always consult a qualified clinician before starting supplements, especially if you take medication or are pregnant or nursing.