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Resveratrol (Trans)

Longevity · circulation · antioxidant

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Resveratrol: Longevity · circulation · antioxidant. Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health. Standard dose 500 mg trans-resveratrol, taken in the morning, about $28/month. Evidence rating: moderate evidence.

What is Resveratrol?

Resveratrol is a polyphenol concentrated in the skins of red grapes, Japanese knotweed, and a handful of berries. Made famous by the 'French paradox', the observation that red-wine drinkers had unexpectedly low rates of heart disease, it has since become one of the most-studied longevity compounds. Resveratrol activates sirtuins (SIRT1 in particular), a family of enzymes that regulate metabolism and cellular repair. Research suggests benefits for endothelial function, blood pressure, and oxidative stress markers. Most supplements provide 250-500 mg of trans-resveratrol (the bioactive isomer) per day, often paired with a fat-containing meal for absorption.

WHY IT MATTERS

Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health.

Natural food sources

Where possible, get Resveratrol from whole foods first. Common dietary sources include:

Red grapesRed wineBlueberriesPeanuts

Where to buy

Doctor's Best Trans-Resveratrol 100mg
RECOMMENDED
Doctor's Best, Resveratrol
500 mg trans-resveratrol · Morning · ~$28/month

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Best for your goal

Interactions

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Common questions

What is Resveratrol?
Resveratrol is a polyphenol concentrated in the skins of red grapes, Japanese knotweed, and a handful of berries. Made famous by the 'French paradox', the observation that red-wine drinkers had unexpectedly low rates of heart disease, it has since become one of the most-studied longevity compounds. Resveratrol activates sirtuins (SIRT1 in particular), a family of enzymes that regulate metabolism and cellular repair. Research suggests benefits for endothelial function, blood pressure, and oxidative stress markers. Most supplements provide 250-500 mg of trans-resveratrol (the bioactive isomer) per day, often paired with a fat-containing meal for absorption.
What is Resveratrol used for?
Longevity · circulation · antioxidant. Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health.
What is the standard dose of Resveratrol?
500 mg trans-resveratrol, typically taken in the morning. Approximate cost is $28 per month.
How strong is the evidence for Resveratrol?
Moderate evidence for its primary uses. See the full study list on the research page.

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