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Resveratrol (Trans)

Longevity · circulation · antioxidant

Moderate evidenceVegan576 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Resveratrol: Longevity · circulation · antioxidant. Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health. Standard dose 500 mg trans-resveratrol, taken in the morning, about $28/month. Evidence rating: moderate evidence.

Where to buy

Doctor's Best Trans-Resveratrol 100mg
Recommended
Doctor's Best, Resveratrol
500 mg trans-resveratrol · Morning · ~$28/month

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Trans-Resveratrol 100mg
Doctor's Best
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Nutricost Resveratrol 600 mgBest Value
Resveratrol 600 mg
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Resveratrol 600 mg
Swanson
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What is Resveratrol?

Resveratrol is a polyphenol concentrated in the skins of red grapes, Japanese knotweed, and a handful of berries. Made famous by the 'French paradox', the observation that red-wine drinkers had unexpectedly low rates of heart disease, it has since become one of the most-studied longevity compounds. Resveratrol activates sirtuins (SIRT1 in particular), a family of enzymes that regulate metabolism and cellular repair. Research suggests benefits for endothelial function, blood pressure, and oxidative stress markers. Most supplements provide 250-500 mg of trans-resveratrol (the bioactive isomer) per day, often paired with a fat-containing meal for absorption.

Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health.

Natural food sources

Where possible, get Resveratrol from whole foods first. Common dietary sources include:

Red grapesRed wineBlueberriesPeanuts

Best for your goal

Interactions

Other antioxidants

Curcumin (with BioPerine)
Inflammation · joint · recovery
CoQ10 (Ubiquinol)
Cellular energy · heart
Alpha-Lipoic Acid (ALA)
Antioxidant · blood sugar · nerve health
Quercetin (with Bromelain)
Immune · allergies · circulation

Common questions

What is Resveratrol?
Resveratrol is a polyphenol concentrated in the skins of red grapes, Japanese knotweed, and a handful of berries. Made famous by the 'French paradox', the observation that red-wine drinkers had unexpectedly low rates of heart disease, it has since become one of the most-studied longevity compounds. Resveratrol activates sirtuins (SIRT1 in particular), a family of enzymes that regulate metabolism and cellular repair. Research suggests benefits for endothelial function, blood pressure, and oxidative stress markers. Most supplements provide 250-500 mg of trans-resveratrol (the bioactive isomer) per day, often paired with a fat-containing meal for absorption.
What is Resveratrol used for?
Longevity · circulation · antioxidant. Polyphenol from grapes and Japanese knotweed that activates longevity pathways (sirtuins) and supports cardiovascular health.
What is the standard dose of Resveratrol?
500 mg trans-resveratrol, typically taken in the morning. Approximate cost is $28 per month.
How strong is the evidence for Resveratrol?
Moderate evidence for its primary uses. See the full study list on the research page.

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