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Artichoke Leaf Extract

Liver · digestion · bile · cholesterol

Strong evidenceVegan73 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Artichoke Leaf Extract: Liver · digestion · bile · cholesterol. Cynarin in artichoke leaf stimulates bile production and is well-evidenced for indigestion and modest cholesterol reduction. Standard dose 320 mg, taken in the morning, about $22/month. Evidence rating: strong evidence.

Where to buy

Solgar Artichoke Leaf Extract
Recommended
Solgar, Artichoke Leaf Extract
320 mg · Morning · ~$22/month

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What is Artichoke Leaf Extract?

Artichoke leaf extract concentrates the bitter compound cynarin, which strongly stimulates bile production and flow from the gallbladder. Bile is essential for fat digestion and for excreting cholesterol, so artichoke supports both digestion and modest cholesterol reduction. Meta-analyses confirm benefits for functional dyspepsia, IBS, and mild hypercholesterolemia. Artichoke leaf also has hepatoprotective effects against toxins. Standard dose is 300-600 mg of extract standardized to 2.5-5% cynarin, before meals.

Cynarin in artichoke leaf stimulates bile production and is well-evidenced for indigestion and modest cholesterol reduction.

Natural food sources

Where possible, get Artichoke Leaf Extract from whole foods first. Common dietary sources include:

Globe artichokesArtichoke heartsJerusalem artichokes

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Common questions

What is Artichoke Leaf Extract?
Artichoke leaf extract concentrates the bitter compound cynarin, which strongly stimulates bile production and flow from the gallbladder. Bile is essential for fat digestion and for excreting cholesterol, so artichoke supports both digestion and modest cholesterol reduction. Meta-analyses confirm benefits for functional dyspepsia, IBS, and mild hypercholesterolemia. Artichoke leaf also has hepatoprotective effects against toxins. Standard dose is 300-600 mg of extract standardized to 2.5-5% cynarin, before meals.
What is Artichoke Leaf Extract used for?
Liver · digestion · bile · cholesterol. Cynarin in artichoke leaf stimulates bile production and is well-evidenced for indigestion and modest cholesterol reduction.
What is the standard dose of Artichoke Leaf Extract?
320 mg, typically taken in the morning. Approximate cost is $22 per month.
How strong is the evidence for Artichoke Leaf Extract?
Strong evidence for its primary uses. See the full study list on the research page.

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