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Huperzine A

Acetylcholine · memory · cognitive sharpness

Strong evidenceVegan35 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Huperzine A: Acetylcholine · memory · cognitive sharpness. Inhibits the breakdown of acetylcholine, raising levels of the brain's primary memory and learning neurotransmitter. Standard dose 200 mcg, taken in the morning, about $18/month. Evidence rating: strong evidence.

Where to buy

Double Wood Huperzine A 200mcg
Recommended
Double Wood, Huperzine A
200 mcg · Morning · ~$18/month

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Double Wood Huperzine A 200mcgBest Value
Huperzine A 200mcg
Double Wood
120 capsules · $18 · ★ 4.6
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Huperzine A 200 mcg
NOW Foods
120 veg caps · $15 · ★ 4.6
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Double Wood Huperzine ABest Value
Huperzine A
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120 capsules · $18 · ★ 4.6
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What is Huperzine A?

Huperzine A is an alkaloid isolated from the Chinese club moss Huperzia serrata. It is a reversible, selective inhibitor of acetylcholinesterase, the enzyme that breaks down acetylcholine, the brain's primary neurotransmitter for memory and learning. Multiple randomized trials in Alzheimer's, vascular dementia, and age-related cognitive decline show meaningful improvements in cognitive scores. For healthy users, it can support sharp focus and memory recall. Huperzine A has a long half-life and should be cycled (5 days on, 2 off) to avoid tolerance. Standard dose is 100-200 mcg per day.

Inhibits the breakdown of acetylcholine, raising levels of the brain's primary memory and learning neurotransmitter.

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Common questions

What is Huperzine A?
Huperzine A is an alkaloid isolated from the Chinese club moss Huperzia serrata. It is a reversible, selective inhibitor of acetylcholinesterase, the enzyme that breaks down acetylcholine, the brain's primary neurotransmitter for memory and learning. Multiple randomized trials in Alzheimer's, vascular dementia, and age-related cognitive decline show meaningful improvements in cognitive scores. For healthy users, it can support sharp focus and memory recall. Huperzine A has a long half-life and should be cycled (5 days on, 2 off) to avoid tolerance. Standard dose is 100-200 mcg per day.
What is Huperzine A used for?
Acetylcholine · memory · cognitive sharpness. Inhibits the breakdown of acetylcholine, raising levels of the brain's primary memory and learning neurotransmitter.
What is the standard dose of Huperzine A?
200 mcg, typically taken in the morning. Approximate cost is $18 per month.
Who should avoid Huperzine A?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing.
How strong is the evidence for Huperzine A?
Strong evidence for its primary uses. See the full study list on the research page.

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