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Saffron Extract (Affron)

Mood · mild low mood · PMS

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Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Saffron Extract: Mood · mild low mood · PMS. Clinically-studied spice extract that supports mood in mild-to-moderate low mood, comparable to first-line interventions in head-to-head trials. Standard dose 28 mg, taken in the morning, about $24/month. Evidence rating: strong evidence.

What is Saffron Extract?

Saffron, the dried stigma of Crocus sativus, is the world's most expensive spice by weight, with a strikingly robust evidence base for emotional well-being. Multiple randomized controlled trials of standardized extracts (Affron and Satiereal are the most-studied) show meaningful improvements in mood, irritability, and PMS symptoms. Head-to-head studies have compared saffron favorably to common first-line mood treatments at clinical doses. Mechanistically, saffron's bioactive compounds (crocin, safranal, picrocrocin) appear to modulate serotonin, dopamine, and norepinephrine pathways. The clinical dose is 28-30 mg of standardized extract daily, with effects typically emerging within 4-6 weeks.

WHY IT MATTERS

Clinically-studied spice extract that supports mood in mild-to-moderate low mood, comparable to first-line interventions in head-to-head trials.

Natural food sources

Where possible, get Saffron Extract from whole foods first. Common dietary sources include:

Saffron threads (cooking spice)Saffron-infused rice dishes

Where to buy

Sports Research Saffron Extract Affron 28mg
RECOMMENDED
Sports Research, Saffron Extract
28 mg · Morning · ~$24/month

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Common questions

What is Saffron Extract?
Saffron, the dried stigma of Crocus sativus, is the world's most expensive spice by weight, with a strikingly robust evidence base for emotional well-being. Multiple randomized controlled trials of standardized extracts (Affron and Satiereal are the most-studied) show meaningful improvements in mood, irritability, and PMS symptoms. Head-to-head studies have compared saffron favorably to common first-line mood treatments at clinical doses. Mechanistically, saffron's bioactive compounds (crocin, safranal, picrocrocin) appear to modulate serotonin, dopamine, and norepinephrine pathways. The clinical dose is 28-30 mg of standardized extract daily, with effects typically emerging within 4-6 weeks.
What is Saffron Extract used for?
Mood · mild low mood · PMS. Clinically-studied spice extract that supports mood in mild-to-moderate low mood, comparable to first-line interventions in head-to-head trials.
What is the standard dose of Saffron Extract?
28 mg, typically taken in the morning. Approximate cost is $24 per month.
Who should avoid Saffron Extract?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing.
How strong is the evidence for Saffron Extract?
Strong evidence for its primary uses. See the full study list on the research page.

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