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ADAPTOGENS

Ashwagandha KSM-66

Stress · cortisol · sleep onset

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Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Ashwagandha KSM-66: Stress · cortisol · sleep onset. A clinically-studied adaptogen that lowers cortisol under chronic stress while preserving daytime alertness. Standard dose 600 mg standardised, taken in the evening, about $17/month. Evidence rating: strong evidence.

What is Ashwagandha KSM-66?

Ashwagandha (Withania somnifera) is the most-studied adaptogenic herb in Ayurvedic medicine, used for over 3,000 years to support resilience to physical and mental stress. The KSM-66 extract, standardized to 5% withanolides and made from the root only, is the gold-standard clinical form, with over 20 published placebo-controlled trials. Research consistently shows reductions in perceived stress, lower cortisol levels in chronically stressed adults, improved sleep onset, and modest improvements in strength and recovery in active populations. The standard dose is 600 mg of KSM-66 per day. Avoid during pregnancy, with autoimmune conditions, or alongside thyroid medication without clinician supervision.

WHY IT MATTERS

A clinically-studied adaptogen that lowers cortisol under chronic stress while preserving daytime alertness.

Where to buy

Jarrow Formulas Ashwagandha KSM-66
RECOMMENDED
Jarrow Formulas, Ashwagandha KSM-66
600 mg standardised · Evening · ~$17/month

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Jarrow Formulas Ashwagandha KSM-66BESTSELLER
Ashwagandha KSM-66
Jarrow Formulas
120 veg capsules · $18 · ★ 4.7
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NOW Foods AshwagandhaBEST VALUE
Ashwagandha
NOW Foods
180 veg capsules · $17 · ★ 4.6
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Solgar Ashwagandha Root ExtractPREMIUM
Ashwagandha Root Extract
Solgar
60 veg capsules · $24 · ★ 4.7
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Stacks that include Ashwagandha KSM-66

☾
The Sleep Stack
Deeper sleep, fewer trips to the bathroom.
♡
The Stress Stack
Calmer baseline, no sedation.

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Interactions

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Common questions

What is Ashwagandha KSM-66?
Ashwagandha (Withania somnifera) is the most-studied adaptogenic herb in Ayurvedic medicine, used for over 3,000 years to support resilience to physical and mental stress. The KSM-66 extract, standardized to 5% withanolides and made from the root only, is the gold-standard clinical form, with over 20 published placebo-controlled trials. Research consistently shows reductions in perceived stress, lower cortisol levels in chronically stressed adults, improved sleep onset, and modest improvements in strength and recovery in active populations. The standard dose is 600 mg of KSM-66 per day. Avoid during pregnancy, with autoimmune conditions, or alongside thyroid medication without clinician supervision.
What is Ashwagandha KSM-66 used for?
Stress · cortisol · sleep onset. A clinically-studied adaptogen that lowers cortisol under chronic stress while preserving daytime alertness.
What is the standard dose of Ashwagandha KSM-66?
600 mg standardised, typically taken in the evening. Approximate cost is $17 per month.
Who should avoid Ashwagandha KSM-66?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing, thyroid condition, autoimmune condition.
How strong is the evidence for Ashwagandha KSM-66?
Strong evidence for its primary uses. See the full study list on the research page.

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