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Ashwagandha KSM-66

Stress · cortisol · sleep onset

Strong evidenceVeganCore ingredient112 studies on PubMedRead the research
Medically reviewed by Sarah Khan, Dietitian· Updated 30 May 2026
Last reviewed: May 30, 2026

Ashwagandha KSM-66: Stress · cortisol · sleep onset. A clinically-studied adaptogen that lowers cortisol and helps build resilience under chronic stress. Standard dose 600 mg standardised, taken in the evening, about $17/month. Evidence rating: strong evidence.

Where to buy

Jarrow Formulas Ashwagandha KSM-66
Recommended
Jarrow Formulas, Ashwagandha KSM-66
600 mg standardised · Evening · ~$17/month

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All product options

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120 veg capsules · $18 · ★ 4.7
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60 veg capsules · $24 · ★ 4.7
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240 capsules · $19 · ★ 4.7
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What is Ashwagandha KSM-66?

Ashwagandha (Withania somnifera) is the most-studied adaptogenic herb in Ayurvedic medicine, used for over 3,000 years to support resilience to physical and mental stress. The KSM-66 extract, standardized to 5% withanolides and made from the root only, is one of the most extensively studied Ashwagandha extracts, with over 20 published placebo-controlled trials. Research consistently shows reductions in perceived stress, lower cortisol levels in chronically stressed adults, improved sleep onset, and modest improvements in strength and recovery in active populations. The standard dose is 600 mg of KSM-66 per day. During pregnancy, with autoimmune or thyroid conditions, or alongside thyroid medication, consult a healthcare professional before use. Rare cases of liver injury have been reported; discontinue use and seek medical attention if symptoms such as jaundice, dark urine, or unexplained fatigue occur.

A clinically-studied adaptogen that lowers cortisol and helps build resilience under chronic stress.

Stacks that include Ashwagandha KSM-66

The Sleep Stack
Deeper sleep, fewer trips to the bathroom.
The Stress Stack
Calmer baseline, no sedation.

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Interactions

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Common questions

What is Ashwagandha KSM-66?
Ashwagandha (Withania somnifera) is the most-studied adaptogenic herb in Ayurvedic medicine, used for over 3,000 years to support resilience to physical and mental stress. The KSM-66 extract, standardized to 5% withanolides and made from the root only, is one of the most extensively studied Ashwagandha extracts, with over 20 published placebo-controlled trials. Research consistently shows reductions in perceived stress, lower cortisol levels in chronically stressed adults, improved sleep onset, and modest improvements in strength and recovery in active populations. The standard dose is 600 mg of KSM-66 per day. During pregnancy, with autoimmune or thyroid conditions, or alongside thyroid medication, consult a healthcare professional before use. Rare cases of liver injury have been reported; discontinue use and seek medical attention if symptoms such as jaundice, dark urine, or unexplained fatigue occur.
What is Ashwagandha KSM-66 used for?
Stress · cortisol · sleep onset. A clinically-studied adaptogen that lowers cortisol and helps build resilience under chronic stress.
What is the standard dose of Ashwagandha KSM-66?
600 mg standardised, typically taken in the evening. Approximate cost is $17 per month.
Who should avoid Ashwagandha KSM-66?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing, thyroid condition, autoimmune condition.
How strong is the evidence for Ashwagandha KSM-66?
Strong evidence for its primary uses. See the full study list on the research page.

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