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NOOTROPICS

Uridine Monophosphate

Synaptic plasticity · memory · mood

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Uridine Monophosphate: Synaptic plasticity · memory · mood. A nucleotide essential for phospholipid synthesis. Supports synaptic plasticity, memory formation, and dopamine signalling. Standard dose 300 mg, taken in the morning, about $24/month. Evidence rating: moderate evidence.

What is Uridine Monophosphate?

Uridine is one of the four building blocks of RNA and a key precursor to phosphatidylcholine and other neural phospholipids. Supplemental uridine monophosphate crosses the blood-brain barrier and supports the formation of new synaptic connections, increases dopamine D1 receptor density, and may enhance the effects of choline-based nootropics. The 'Mr. Happy stack' (uridine + omega-3 DHA + choline) is widely used for mood and cognitive support. Clinical evidence is strongest in pediatric and elderly populations; recreational nootropic use is supported by mechanistic data and anecdotal reports. Standard sublingual dose is 150-300 mg per day.

WHY IT MATTERS

A nucleotide essential for phospholipid synthesis. Supports synaptic plasticity, memory formation, and dopamine signalling.

Natural food sources

Where possible, get Uridine Monophosphate from whole foods first. Common dietary sources include:

Brewer's yeastOrgan meatsBroccoliBeer

Where to buy

Nutricost Uridine Monophosphate 300mg
RECOMMENDED
Double Wood, Uridine Monophosphate
300 mg · Morning · ~$24/month

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Common questions

What is Uridine Monophosphate?
Uridine is one of the four building blocks of RNA and a key precursor to phosphatidylcholine and other neural phospholipids. Supplemental uridine monophosphate crosses the blood-brain barrier and supports the formation of new synaptic connections, increases dopamine D1 receptor density, and may enhance the effects of choline-based nootropics. The 'Mr. Happy stack' (uridine + omega-3 DHA + choline) is widely used for mood and cognitive support. Clinical evidence is strongest in pediatric and elderly populations; recreational nootropic use is supported by mechanistic data and anecdotal reports. Standard sublingual dose is 150-300 mg per day.
What is Uridine Monophosphate used for?
Synaptic plasticity · memory · mood. A nucleotide essential for phospholipid synthesis. Supports synaptic plasticity, memory formation, and dopamine signalling.
What is the standard dose of Uridine Monophosphate?
300 mg, typically taken in the morning. Approximate cost is $24 per month.
How strong is the evidence for Uridine Monophosphate?
Moderate evidence for its primary uses. See the full study list on the research page.

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