Home/Ingredients/Riboflavin (B2), Activated

Riboflavin (B2), Activated

Energy · migraine · mitochondrial

Strong evidenceVegan135 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Riboflavin: Energy · migraine · mitochondrial. Cofactor in cellular energy production. High-dose riboflavin is one of the few well-evidenced nutritional interventions for migraine prevention. Standard dose 100 mg, taken in the morning, about $10/month. Evidence rating: strong evidence.

Where to buy

NOW Foods Riboflavin (B2) 100mg
Recommended
NOW Foods, Riboflavin
100 mg · Morning · ~$10/month

suppdoc.io is an affiliate. Links may earn us a commission at no extra cost to you.

All product options

NOW Foods Riboflavin (B2) 100mgBestseller
Riboflavin (B2) 100mg
NOW Foods
100 capsules · $9 · ★ 4.8
Buy on iHerb →Buy on Amazon →
NOW Foods Vitamin B-2 100 mgBestseller
Vitamin B-2 100 mg
NOW Foods
100 capsules · $8 · ★ 4.7
Buy on iHerb →
Solgar Vitamin B2 (Riboflavin)Best Value
Vitamin B2 (Riboflavin)
Solgar
100 capsules · $11 · ★ 4.6
Buy on iHerb →
Source Naturals Riboflavin B-2Premium
Riboflavin B-2
Source Naturals
100 tablets · $10 · ★ 4.5
Buy on iHerb →
Nutricost Riboflavin (B2)Premium
Riboflavin (B2)
Nutricost
120 capsules · $13 · ★ 4.5
Buy on iHerb →

What is Riboflavin?

Riboflavin (vitamin B2) is essential for converting food into cellular energy. Inside cells, it is incorporated into the cofactors FAD and FMN, which power the electron transport chain in mitochondria, the site of ATP production. Beyond foundational energy metabolism, high-dose riboflavin (400 mg/day) has unusually strong clinical evidence for the prevention of migraine headaches, with effects building over 8-12 weeks. It is also necessary for the recycling of glutathione, the body's master antioxidant, and for activating other B vitamins. Standard supplemental doses are 25-100 mg daily for general support, or 400 mg for migraine prevention. A harmless bright yellow urine is normal.

Cofactor in cellular energy production. High-dose riboflavin is one of the few well-evidenced nutritional interventions for migraine prevention.

Natural food sources

Where possible, get Riboflavin from whole foods first. Common dietary sources include:

Dairy (milk, yogurt)EggsAlmondsLean meatsLeafy greens

Best for your goal

Other vitamins

Vitamin D3 + K2
Energy · bone · immune
Whole-food Multivitamin
Baseline nutrition
Methyl-B12
Energy · nerves · cognition
B-Complex
Energy · stress · methylation

Common questions

What is Riboflavin?
Riboflavin (vitamin B2) is essential for converting food into cellular energy. Inside cells, it is incorporated into the cofactors FAD and FMN, which power the electron transport chain in mitochondria, the site of ATP production. Beyond foundational energy metabolism, high-dose riboflavin (400 mg/day) has unusually strong clinical evidence for the prevention of migraine headaches, with effects building over 8-12 weeks. It is also necessary for the recycling of glutathione, the body's master antioxidant, and for activating other B vitamins. Standard supplemental doses are 25-100 mg daily for general support, or 400 mg for migraine prevention. A harmless bright yellow urine is normal.
What is Riboflavin used for?
Energy · migraine · mitochondrial. Cofactor in cellular energy production. High-dose riboflavin is one of the few well-evidenced nutritional interventions for migraine prevention.
What is the standard dose of Riboflavin?
100 mg, typically taken in the morning. Approximate cost is $10 per month.
How strong is the evidence for Riboflavin?
Strong evidence for its primary uses. See the full study list on the research page.

Not sure if Riboflavin is right for you?

Take our quiz. We'll compose a personalised stack that fits your goals, body, and budget, in minutes.

Take the quiz →