Does Glycine interact with Magnesium Glycinate?

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Take together· moderate evidence

Calming sleep pairing.

Glycine is a calming neurotransmitter that gently lowers core body temperature to help you drop off, while magnesium quiets an over-active nervous system and relaxes muscle, so the two support sleep onset and depth through different routes.

What to do

A gentle, well-tolerated evening combination. Take roughly 3 g of glycine with 200 to 400 mg of magnesium glycinate (which itself supplies extra glycine) about 30 to 60 minutes before bed, and keep the magnesium modest if you are prone to loose stools.

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Glycine
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Magnesium Glycinate
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Common questions

Can I take Glycine and Magnesium Glycinate together?
Take together. A gentle, well-tolerated evening combination. Take roughly 3 g of glycine with 200 to 400 mg of magnesium glycinate (which itself supplies extra glycine) about 30 to 60 minutes before bed, and keep the magnesium modest if you are prone to loose stools.
Why do Glycine and Magnesium Glycinate interact?
Glycine is a calming neurotransmitter that gently lowers core body temperature to help you drop off, while magnesium quiets an over-active nervous system and relaxes muscle, so the two support sleep onset and depth through different routes.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.