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HORMONAL SUPPORT

DIM (Diindolylmethane)

Estrogen metabolism · hormonal balance

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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DIM: Estrogen metabolism · hormonal balance. Active compound concentrated from cruciferous vegetables. Supports favorable 2:16 ratio of estrogen metabolites, relevant for both women and men. Standard dose 100 mg, taken in the morning, about $26/month. Evidence rating: moderate evidence.

What is DIM?

Diindolylmethane (DIM) is a bioactive compound formed in the stomach when indole-3-carbinol from cruciferous vegetables, broccoli, kale, cauliflower, cabbage, is exposed to gastric acid. You would need to eat about 2 pounds of broccoli to get the equivalent of a typical DIM supplement. DIM modulates estrogen metabolism by shifting the balance toward the favorable 2-hydroxyestrone pathway and away from the less-desirable 16-hydroxyestrone pathway. This affects both women (PMS, cyclical breast tenderness, estrogen dominance) and men (where excess estrogen can disrupt the testosterone-to-estrogen ratio). Standard dose is 100-200 mg per day with food.

WHY IT MATTERS

Active compound concentrated from cruciferous vegetables. Supports favorable 2:16 ratio of estrogen metabolites, relevant for both women and men.

Natural food sources

Where possible, get DIM from whole foods first. Common dietary sources include:

BroccoliCauliflowerCabbageKaleBrussels sprouts

Where to buy

Pure Encapsulations DIM Detox
RECOMMENDED
Pure Encapsulations, DIM
100 mg · Morning · ~$26/month

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Common questions

What is DIM?
Diindolylmethane (DIM) is a bioactive compound formed in the stomach when indole-3-carbinol from cruciferous vegetables, broccoli, kale, cauliflower, cabbage, is exposed to gastric acid. You would need to eat about 2 pounds of broccoli to get the equivalent of a typical DIM supplement. DIM modulates estrogen metabolism by shifting the balance toward the favorable 2-hydroxyestrone pathway and away from the less-desirable 16-hydroxyestrone pathway. This affects both women (PMS, cyclical breast tenderness, estrogen dominance) and men (where excess estrogen can disrupt the testosterone-to-estrogen ratio). Standard dose is 100-200 mg per day with food.
What is DIM used for?
Estrogen metabolism · hormonal balance. Active compound concentrated from cruciferous vegetables. Supports favorable 2:16 ratio of estrogen metabolites, relevant for both women and men.
What is the standard dose of DIM?
100 mg, typically taken in the morning. Approximate cost is $26 per month.
Who should avoid DIM?
Use extra caution, and speak to a clinician first, if you are pregnant or nursing.
How strong is the evidence for DIM?
Moderate evidence for its primary uses. See the full study list on the research page.

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