Does CoQ10 interact with PQQ?

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Take together· moderate evidence

Mitochondrial duo.

CoQ10 keeps your existing mitochondria producing energy and acts as an antioxidant inside them, while PQQ is thought to encourage the creation of new mitochondria, so the pair supports both the function and the number of your cells' power plants.

What to do

A common, well-tolerated pairing for energy and healthy aging. Both are fat-soluble, so take them with a meal that contains fat, and give it several weeks. Ubiquinol is the better-absorbed CoQ10 form for people over about 40.

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CoQ10
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PQQ
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Common questions

Can I take CoQ10 and PQQ together?
Take together. A common, well-tolerated pairing for energy and healthy aging. Both are fat-soluble, so take them with a meal that contains fat, and give it several weeks. Ubiquinol is the better-absorbed CoQ10 form for people over about 40.
Why do CoQ10 and PQQ interact?
CoQ10 keeps your existing mitochondria producing energy and acts as an antioxidant inside them, while PQQ is thought to encourage the creation of new mitochondria, so the pair supports both the function and the number of your cells' power plants.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.