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ANTIOXIDANTS

PQQ (Pyrroloquinoline Quinone)

Mitochondrial biogenesis · cellular energy

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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PQQ: Mitochondrial biogenesis · cellular energy. One of the few compounds shown to support the creation of new mitochondria, the energy factories of every cell. Standard dose 20 mg, taken in the morning, about $32/month. Evidence rating: moderate evidence.

What is PQQ?

Pyrroloquinoline Quinone (PQQ) is a small redox cofactor found in trace amounts in fermented foods, kiwi, parsley, and green tea. What makes PQQ unique among supplements is its documented ability to stimulate mitochondrial biogenesis, the creation of brand-new mitochondria within cells. Because mitochondrial density drives cellular energy output, PQQ has gained attention for supporting daytime energy, exercise capacity, and cognitive function with aging. It also functions as a potent antioxidant. Clinical studies typically use 10-20 mg per day. PQQ pairs well with CoQ10 or ubiquinol for full mitochondrial support.

WHY IT MATTERS

One of the few compounds shown to support the creation of new mitochondria, the energy factories of every cell.

Natural food sources

Where possible, get PQQ from whole foods first. Common dietary sources include:

NattoParsleyGreen teaKiwi

Where to buy

Life Extension PQQ Caps 20mg
RECOMMENDED
Life Extension, PQQ
20 mg · Morning · ~$32/month

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Best for your goal

Interactions

Other antioxidants

Curcumin (with BioPerine)
Inflammation · joint · recovery
CoQ10 (Ubiquinol)
Cellular energy · heart
Alpha-Lipoic Acid (ALA)
Antioxidant · blood sugar · nerve health
Quercetin (with Bromelain)
Immune · allergies · circulation

Common questions

What is PQQ?
Pyrroloquinoline Quinone (PQQ) is a small redox cofactor found in trace amounts in fermented foods, kiwi, parsley, and green tea. What makes PQQ unique among supplements is its documented ability to stimulate mitochondrial biogenesis, the creation of brand-new mitochondria within cells. Because mitochondrial density drives cellular energy output, PQQ has gained attention for supporting daytime energy, exercise capacity, and cognitive function with aging. It also functions as a potent antioxidant. Clinical studies typically use 10-20 mg per day. PQQ pairs well with CoQ10 or ubiquinol for full mitochondrial support.
What is PQQ used for?
Mitochondrial biogenesis · cellular energy. One of the few compounds shown to support the creation of new mitochondria, the energy factories of every cell.
What is the standard dose of PQQ?
20 mg, typically taken in the morning. Approximate cost is $32 per month.
How strong is the evidence for PQQ?
Moderate evidence for its primary uses. See the full study list on the research page.

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