Does Multi-Strain Probiotic interact with Saccharomyces boulardii?

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Take together· moderate evidence

Bacteria plus beneficial yeast.

S. boulardii is a friendly yeast rather than a bacterium, so it is not killed by antibiotics and works alongside bacterial probiotics, and it is best evidenced for preventing antibiotic-associated and traveller's diarrhoea.

What to do

A sensible combination, especially during and after antibiotics or while travelling. You can take S. boulardii at the same time as antibiotics, unlike bacterial probiotics, which are better spaced a couple of hours apart. Anyone immunocompromised or with a central line should check with a doctor first.

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Multi-Strain Probiotic
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Saccharomyces boulardii
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Common questions

Can I take Multi-Strain Probiotic and Saccharomyces boulardii together?
Take together. A sensible combination, especially during and after antibiotics or while travelling. You can take S. boulardii at the same time as antibiotics, unlike bacterial probiotics, which are better spaced a couple of hours apart. Anyone immunocompromised or with a central line should check with a doctor first.
Why do Multi-Strain Probiotic and Saccharomyces boulardii interact?
S. boulardii is a friendly yeast rather than a bacterium, so it is not killed by antibiotics and works alongside bacterial probiotics, and it is best evidenced for preventing antibiotic-associated and traveller's diarrhoea.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.