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Saccharomyces boulardii

Antibiotic-associated diarrhea · gut yeast

Very strong evidenceVegan196 studies on PubMedRead the research
Written to our editorial standards · reviewed against published research· Updated 30 May 2026
Last reviewed: May 30, 2026

Saccharomyces boulardii: Antibiotic-associated diarrhea · gut yeast. A beneficial yeast probiotic. The best-evidenced supplement for preventing antibiotic-associated diarrhea. Standard dose 5 billion CFU, taken in the morning, about $22/month. Evidence rating: very strong evidence.

Where to buy

Jarrow Formulas Saccharomyces Boulardii + MOS
Recommended
Jarrow Formulas, Saccharomyces boulardii
5 billion CFU · Morning · ~$22/month

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All product options

Jarrow Formulas Saccharomyces Boulardii + MOSBestseller
Saccharomyces Boulardii + MOS
Jarrow Formulas
90 capsules · $22 · ★ 4.7
Buy on iHerb →Buy on Amazon →
NOW Foods Saccharomyces BoulardiiBest Value
Saccharomyces Boulardii
NOW Foods
120 veg caps · $22 · ★ 4.6
Buy on iHerb →
Swanson S. Boulardii ProbioticPremium
S. Boulardii Probiotic
Swanson
60 veg caps · $16 · ★ 4.5
Buy on iHerb →
Pure Encapsulations Saccharomyces BoulardiiPremium
Saccharomyces Boulardii
Pure Encapsulations
120 capsules · $40 · ★ 4.7
Buy on iHerb →

What is Saccharomyces boulardii?

Saccharomyces boulardii is a non-pathogenic tropical yeast first isolated from lychee fruit in 1923. Unlike bacterial probiotics, it is resistant to antibiotics and stomach acid, surviving transit to reach the colon intact. Meta-analyses of dozens of randomized controlled trials consistently support S. boulardii for preventing antibiotic-associated diarrhea (reduces risk by ~50%), traveler's diarrhea, and recurrent C. difficile infection. It also shows benefit in IBS, H. pylori protocols, and pediatric acute gastroenteritis. Standard dose is 5-10 billion CFU per day, especially during and 2 weeks after antibiotic courses.

A beneficial yeast probiotic. The best-evidenced supplement for preventing antibiotic-associated diarrhea.

Stacks that include Saccharomyces boulardii

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The Gut Reset Stack
Repair the lining. Rebalance the microbiome.

Best for your goal

Interactions

Other gut & digestive

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Gut · immunity · mood
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Fiber · cholesterol · regularity
Inulin (Prebiotic Fiber)
Prebiotic · gut microbiome · regularity

Common questions

What is Saccharomyces boulardii?
Saccharomyces boulardii is a non-pathogenic tropical yeast first isolated from lychee fruit in 1923. Unlike bacterial probiotics, it is resistant to antibiotics and stomach acid, surviving transit to reach the colon intact. Meta-analyses of dozens of randomized controlled trials consistently support S. boulardii for preventing antibiotic-associated diarrhea (reduces risk by ~50%), traveler's diarrhea, and recurrent C. difficile infection. It also shows benefit in IBS, H. pylori protocols, and pediatric acute gastroenteritis. Standard dose is 5-10 billion CFU per day, especially during and 2 weeks after antibiotic courses.
What is Saccharomyces boulardii used for?
Antibiotic-associated diarrhea · gut yeast. A beneficial yeast probiotic. The best-evidenced supplement for preventing antibiotic-associated diarrhea.
What is the standard dose of Saccharomyces boulardii?
5 billion CFU, typically taken in the morning. Approximate cost is $22 per month.
How strong is the evidence for Saccharomyces boulardii?
Very strong evidence for its primary uses. See the full study list on the research page.

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