Best time to take Saccharomyces boulardii

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Anytime; safe alongside antibiotics

Take S. boulardii any time, and unlike bacterial probiotics it is safe taken with antibiotics.

S. boulardii is a beneficial yeast, so antibiotics do not kill it, which is exactly why it is used during and after a course to reduce antibiotic-associated diarrhoea.

When
Anytime
With food?
With or without food
Typical dose
5 billion CFU
How to take it

Take it daily, including alongside antibiotics and for a week or two after. With or without food is fine.

Watch out

Anyone immunocompromised or with a central line should check with a doctor first.

Full guide
Saccharomyces boulardii: benefits, dose & evidence
Read the ingredient guide →

Common questions

When is the best time to take Saccharomyces boulardii?
Take S. boulardii any time, and unlike bacterial probiotics it is safe taken with antibiotics. Take it daily, including alongside antibiotics and for a week or two after. With or without food is fine.
Should I take Saccharomyces boulardii with or without food?
With or without food. S. boulardii is a beneficial yeast, so antibiotics do not kill it, which is exactly why it is used during and after a course to reduce antibiotic-associated diarrhoea.
Anything to watch out for with Saccharomyces boulardii timing?
Anyone immunocompromised or with a central line should check with a doctor first.

Explore further

Saccharomyces boulardii interactions

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Educational use only, not medical advice. The right timing and dose depend on your health, your other supplements, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.