Does Red Yeast Rice interact with Niacinamide?

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Check with a clinician· moderate evidence

Two lipid agents on the liver.

Red yeast rice contains monacolin K, chemically the same as the statin lovastatin, and high-dose niacin (vitamin B3) is itself a lipid-lowering agent. Both are processed by the liver and together can raise liver enzymes and, rarely, cause muscle problems.

What to do

Do not stack these without medical supervision and periodic liver-enzyme and muscle monitoring. If you are already on a statin, treat red yeast rice as a duplicate and avoid adding it.

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Red Yeast Rice
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Niacinamide
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Common questions

Can I take Red Yeast Rice and Niacinamide together?
Check with a clinician. Do not stack these without medical supervision and periodic liver-enzyme and muscle monitoring. If you are already on a statin, treat red yeast rice as a duplicate and avoid adding it.
Why do Red Yeast Rice and Niacinamide interact?
Red yeast rice contains monacolin K, chemically the same as the statin lovastatin, and high-dose niacin (vitamin B3) is itself a lipid-lowering agent. Both are processed by the liver and together can raise liver enzymes and, rarely, cause muscle problems.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.