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Glutathione (Setria)

Master antioxidant · liver · skin · detox

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Glutathione: Master antioxidant · liver · skin · detox. The body's master antioxidant. The Setria form is the only oral glutathione clinically shown to raise blood levels. Standard dose 500 mg, taken in the morning, about $35/month. Evidence rating: moderate evidence.

What is Glutathione?

Glutathione is the body's master antioxidant, present in every cell and central to detoxification, immune function, and antioxidant defense. Levels fall with age and oxidative stress. Most oral glutathione is destroyed in the gut, but the patented Setria form, produced via fermentation by Kyowa Hakko, has been shown in a placebo-controlled trial to raise blood, red blood cell, and lymphocyte glutathione levels after 6 months at 1000 mg/day. Standard dose is 250-1000 mg per day. NAC and glycine are precursors that more reliably raise endogenous glutathione synthesis.

WHY IT MATTERS

The body's master antioxidant. The Setria form is the only oral glutathione clinically shown to raise blood levels.

Natural food sources

Where possible, get Glutathione from whole foods first. Common dietary sources include:

AsparagusAvocadoSpinachOkraGarlic

Where to buy

Jarrow Formulas Setria Glutathione 500mg
RECOMMENDED
Jarrow Formulas, Glutathione
500 mg · Morning · ~$35/month

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Common questions

What is Glutathione?
Glutathione is the body's master antioxidant, present in every cell and central to detoxification, immune function, and antioxidant defense. Levels fall with age and oxidative stress. Most oral glutathione is destroyed in the gut, but the patented Setria form, produced via fermentation by Kyowa Hakko, has been shown in a placebo-controlled trial to raise blood, red blood cell, and lymphocyte glutathione levels after 6 months at 1000 mg/day. Standard dose is 250-1000 mg per day. NAC and glycine are precursors that more reliably raise endogenous glutathione synthesis.
What is Glutathione used for?
Master antioxidant · liver · skin · detox. The body's master antioxidant. The Setria form is the only oral glutathione clinically shown to raise blood levels.
What is the standard dose of Glutathione?
500 mg, typically taken in the morning. Approximate cost is $35 per month.
How strong is the evidence for Glutathione?
Moderate evidence for its primary uses. See the full study list on the research page.

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