Does Vitamin C interact with Glutathione?

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Take together· moderate evidence

Vitamin C spares glutathione.

Vitamin C and glutathione back each other up: vitamin C helps keep glutathione in its active, reduced form, and glutathione in turn helps regenerate vitamin C, so each spares the other and extends its antioxidant life.

What to do

A reasonable antioxidant combination, though a diet rich in fruit and vegetables plus adequate vitamin C does much of this naturally. If you supplement, modest doses are fine; mega-dosing vitamin C mostly leads to it being excreted.

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Vitamin C
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Glutathione
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Common questions

Can I take Vitamin C and Glutathione together?
Take together. A reasonable antioxidant combination, though a diet rich in fruit and vegetables plus adequate vitamin C does much of this naturally. If you supplement, modest doses are fine; mega-dosing vitamin C mostly leads to it being excreted.
Why do Vitamin C and Glutathione interact?
Vitamin C and glutathione back each other up: vitamin C helps keep glutathione in its active, reduced form, and glutathione in turn helps regenerate vitamin C, so each spares the other and extends its antioxidant life.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.