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NOOTROPICS

Phosphatidylserine (PS)

Cortisol · memory · stress recovery

MODERATE EVIDENCEREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Phosphatidylserine: Cortisol · memory · stress recovery. Phospholipid that blunts cortisol response to mental and physical stress, and supports memory function with aging. Standard dose 100 mg, taken in the evening, about $22/month. Evidence rating: moderate evidence.

What is Phosphatidylserine?

Phosphatidylserine (PS) is a phospholipid concentrated in cell membranes, particularly within neurons. Its supplementation has two distinct evidence-based applications. First, in adults with age-related memory complaints, PS has been shown to support memory recall, recognition, and processing speed. Second, in stressed populations, PS appears to blunt the cortisol response to physical and mental stressors, a finding particularly relevant for athletes managing overtraining and for high-stress professionals. Most studies use 100 mg three times daily, though 100-300 mg once daily is also effective. PS is typically derived from soy lecithin or sunflower lecithin.

WHY IT MATTERS

Phospholipid that blunts cortisol response to mental and physical stress, and supports memory function with aging.

Natural food sources

Where possible, get Phosphatidylserine from whole foods first. Common dietary sources include:

Organ meats (liver)Mackerel & herringSoybeansEgg yolks

Where to buy

Doctor's Best Phosphatidylserine 100mg
RECOMMENDED
Doctor's Best, Phosphatidylserine
100 mg · Evening · ~$22/month

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Common questions

What is Phosphatidylserine?
Phosphatidylserine (PS) is a phospholipid concentrated in cell membranes, particularly within neurons. Its supplementation has two distinct evidence-based applications. First, in adults with age-related memory complaints, PS has been shown to support memory recall, recognition, and processing speed. Second, in stressed populations, PS appears to blunt the cortisol response to physical and mental stressors, a finding particularly relevant for athletes managing overtraining and for high-stress professionals. Most studies use 100 mg three times daily, though 100-300 mg once daily is also effective. PS is typically derived from soy lecithin or sunflower lecithin.
What is Phosphatidylserine used for?
Cortisol · memory · stress recovery. Phospholipid that blunts cortisol response to mental and physical stress, and supports memory function with aging.
What is the standard dose of Phosphatidylserine?
100 mg, typically taken in the evening. Approximate cost is $22 per month.
How strong is the evidence for Phosphatidylserine?
Moderate evidence for its primary uses. See the full study list on the research page.

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