Best time to take Phosphatidylserine

Written to our editorial standards · reviewed against published research· Updated 27 Jun 2026
With a meal; evening for stress

Take phosphatidylserine with a meal; an evening dose can blunt stress and cortisol.

Phosphatidylserine is a fat-soluble membrane phospholipid, so food aids absorption, and because it can lower an exaggerated cortisol response, an evening dose helps stress-related sleep issues.

When
Take with food
With food?
With a fat-containing meal
Typical dose
100 mg
How to take it

Take around 100 mg with a meal containing fat, evening if cortisol or stress is the target.

Watch out

An empty stomach lowers absorption.

Shop Phosphatidylserine
Doctor's Best Phosphatidylserine 100mg
Recommended
Doctor's Best, Phosphatidylserine 100mg
60 veg softgels · ~$22 · ★ 4.7

suppdoc.io is an affiliate. Links may earn us a commission at no extra cost to you. We don't sell our own supplements.

Common questions

When is the best time to take Phosphatidylserine?
Take phosphatidylserine with a meal; an evening dose can blunt stress and cortisol. Take around 100 mg with a meal containing fat, evening if cortisol or stress is the target.
Should I take Phosphatidylserine with or without food?
With a fat-containing meal. Phosphatidylserine is a fat-soluble membrane phospholipid, so food aids absorption, and because it can lower an exaggerated cortisol response, an evening dose helps stress-related sleep issues.
Anything to watch out for with Phosphatidylserine timing?
An empty stomach lowers absorption.

Explore further

Phosphatidylserine interactions

Build a stack with the timing built in

Answer a few questions and get a personalised stack, each pick with its dose, timing, and what to take it with.

Take the free quiz →

Educational use only, not medical advice. The right timing and dose depend on your health, your other supplements, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.