Best time to take Phosphatidylserine

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
With a meal; evening for stress

Take phosphatidylserine with a meal; an evening dose can blunt stress and cortisol.

Phosphatidylserine is a fat-soluble membrane phospholipid, so food aids absorption, and because it can lower an exaggerated cortisol response, an evening dose helps stress-related sleep issues.

When
Take with food
With food?
With a fat-containing meal
Typical dose
100 mg
How to take it

Take around 100 mg with a meal containing fat, evening if cortisol or stress is the target.

Watch out

An empty stomach lowers absorption.

Full guide
Phosphatidylserine: benefits, dose & evidence
Read the ingredient guide →

Common questions

When is the best time to take Phosphatidylserine?
Take phosphatidylserine with a meal; an evening dose can blunt stress and cortisol. Take around 100 mg with a meal containing fat, evening if cortisol or stress is the target.
Should I take Phosphatidylserine with or without food?
With a fat-containing meal. Phosphatidylserine is a fat-soluble membrane phospholipid, so food aids absorption, and because it can lower an exaggerated cortisol response, an evening dose helps stress-related sleep issues.
Anything to watch out for with Phosphatidylserine timing?
An empty stomach lowers absorption.

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Phosphatidylserine interactions

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Educational use only, not medical advice. The right timing and dose depend on your health, your other supplements, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.