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AMINO ACIDS

TMG (Trimethylglycine / Betaine)

Methyl donor · homocysteine · NAD+ co-factor

STRONG EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

TMG: Methyl donor · homocysteine · NAD+ co-factor. A methyl donor that lowers homocysteine and replenishes methyl groups consumed by NAD+ precursors like NMN and NR. Standard dose 1000 mg, taken in the morning, about $14/month. Evidence rating: strong evidence.

What is TMG?

Trimethylglycine (TMG), also known as betaine anhydrous, is a methyl donor that supports the conversion of homocysteine to methionine, an important pathway for cardiovascular health and DNA methylation. TMG is particularly relevant for anyone taking NAD+ precursors (NMN, NR), since methylating excess nicotinamide consumes methyl groups; TMG replaces them. Clinical trials at 1.5-4 g/day show meaningful reductions in elevated homocysteine. TMG is also studied for athletic performance, with research suggesting small improvements in power output and body composition. Standard dose is 500-2000 mg per day.

WHY IT MATTERS

A methyl donor that lowers homocysteine and replenishes methyl groups consumed by NAD+ precursors like NMN and NR.

Natural food sources

Where possible, get TMG from whole foods first. Common dietary sources include:

BeetsSpinachWhole grainsQuinoaWheat bran

Where to buy

NOW Foods TMG 1000mg
RECOMMENDED
NOW Foods, TMG
1000 mg · Morning · ~$14/month

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Stacks that include TMG

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The Longevity Blueprint
The frontier protocol for slower biological aging.

Best for your goal

Interactions

Related biomarkers

Other amino acids

L-Theanine (Suntheanine)
Calm focus · stress
Glycine
Sleep depth · core body temperature
N-Acetyl Cysteine (NAC)
Liver · antioxidant · respiratory
Taurine
Heart · sleep · cellular hydration

Common questions

What is TMG?
Trimethylglycine (TMG), also known as betaine anhydrous, is a methyl donor that supports the conversion of homocysteine to methionine, an important pathway for cardiovascular health and DNA methylation. TMG is particularly relevant for anyone taking NAD+ precursors (NMN, NR), since methylating excess nicotinamide consumes methyl groups; TMG replaces them. Clinical trials at 1.5-4 g/day show meaningful reductions in elevated homocysteine. TMG is also studied for athletic performance, with research suggesting small improvements in power output and body composition. Standard dose is 500-2000 mg per day.
What is TMG used for?
Methyl donor · homocysteine · NAD+ co-factor. A methyl donor that lowers homocysteine and replenishes methyl groups consumed by NAD+ precursors like NMN and NR.
What is the standard dose of TMG?
1000 mg, typically taken in the morning. Approximate cost is $14 per month.
How strong is the evidence for TMG?
Strong evidence for its primary uses. See the full study list on the research page.

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